ENSMUSG00000058589


Mus musculus

Features
Gene ID: ENSMUSG00000058589
  
Biological name :Anks1b
  
Synonyms : Anks1b / ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 6
  
Possible biological names infered from orthology : ankyrin repeat and sterile alpha motif domain containing 1B / Q7Z6G8
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 89873509
Gene end: 90973300
  
Corresponding Affymetrix probe sets: 10365682 (MoGene1.0st)   1431229_at (Mouse Genome 430 2.0 Array)   1440944_at (Mouse Genome 430 2.0 Array)   1447464_at (Mouse Genome 430 2.0 Array)   1449634_a_at (Mouse Genome 430 2.0 Array)   1452938_at (Mouse Genome 430 2.0 Array)   1457990_at (Mouse Genome 430 2.0 Array)   1460449_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138679
Ensembl peptide - ENSMUSP00000138667
Ensembl peptide - ENSMUSP00000138701
Ensembl peptide - ENSMUSP00000138794
Ensembl peptide - ENSMUSP00000138738
Ensembl peptide - ENSMUSP00000138720
Ensembl peptide - ENSMUSP00000096965
Ensembl peptide - ENSMUSP00000096967
Ensembl peptide - ENSMUSP00000096968
Ensembl peptide - ENSMUSP00000136146
Ensembl peptide - ENSMUSP00000136410
Ensembl peptide - ENSMUSP00000138209
Ensembl peptide - ENSMUSP00000138222
Ensembl peptide - ENSMUSP00000138234
Ensembl peptide - ENSMUSP00000138256
Ensembl peptide - ENSMUSP00000138314
Ensembl peptide - ENSMUSP00000138398
Ensembl peptide - ENSMUSP00000138480
Ensembl peptide - ENSMUSP00000138539
Ensembl peptide - ENSMUSP00000138576
Ensembl peptide - ENSMUSP00000138610
Ensembl peptide - ENSMUSP00000138614
Ensembl peptide - ENSMUSP00000138643
Ensembl peptide - ENSMUSP00000138644
Ensembl peptide - ENSMUSP00000138650
Ensembl peptide - ENSMUSP00000138655
Ensembl peptide - ENSMUSP00000138660
NCBI entrez gene - 77531     See in Manteia.
MGI - MGI:1924781
RefSeq - XM_017314162
RefSeq - NM_001177396
RefSeq - NM_001177397
RefSeq - NM_001177398
RefSeq - NM_181398
RefSeq - XM_006514301
RefSeq - XM_006514302
RefSeq - XM_006514303
RefSeq - XM_006514304
RefSeq - XM_006514305
RefSeq - XM_006514306
RefSeq - XM_006514307
RefSeq - XM_006514308
RefSeq - XM_006514309
RefSeq - XM_006514310
RefSeq - XM_006514311
RefSeq - XM_006514312
RefSeq - XM_006514313
RefSeq - XM_006514314
RefSeq - XM_006514315
RefSeq - XM_017314148
RefSeq - XM_017314149
RefSeq - XM_017314150
RefSeq - XM_017314151
RefSeq - XM_017314152
RefSeq - XM_017314153
RefSeq - XM_017314154
RefSeq - XM_017314155
RefSeq - XM_017314156
RefSeq - XM_017314157
RefSeq - XM_017314158
RefSeq - XM_017314159
RefSeq - XM_017314160
RefSeq - XM_017314161
RefSeq - NM_001128086
RefSeq Peptide - NP_852063
RefSeq Peptide - NP_001121558
RefSeq Peptide - NP_001170867
RefSeq Peptide - NP_001170868
RefSeq Peptide - NP_001170869
RefSeq Peptide - NP_001333982
RefSeq Peptide - NP_001333983
RefSeq Peptide - NP_001346171
swissprot - S4R2Q2
swissprot - A0A0R4J2A2
swissprot - S4R1G5
swissprot - S4R1H2
swissprot - S4R1K4
swissprot - S4R1Q0
swissprot - S4R1W3
swissprot - S4R235
swissprot - S4R286
swissprot - S4R2B3
swissprot - S4R2E3
swissprot - S4R2E7
swissprot - S4R2H2
swissprot - S4R2H3
swissprot - S4R2H8
swissprot - S4R2I2
swissprot - E9QPP6
swissprot - S4R2J3
swissprot - A0A140T8U6
swissprot - A0A0R4J2A8
swissprot - K4DI73
swissprot - A0A0R4J2A6
swissprot - S4R2K2
swissprot - S4R2M2
swissprot - S4R2N9
Ensembl - ENSMUSG00000058589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5PMU4ENSDARG00000003512Danio rerio
 ANKS1BENSGALG00000011549Gallus gallus
 ANKS1BENSG00000185046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anks1 / P59672 / Ankyrin repeat and SAM domain-containing protein 1A / Q92625* / ANKS1A* / ankyrin repeat and sterile alpha motif domain containing 1A*ENSMUSG0000002421954
Q6P9K8 / Caskin1 / Q8WXD9* / CASK interacting protein 1*ENSMUSG0000003359721
Q8VHK1 / Caskin2 / Q8WXE0* / CASK interacting protein 2*ENSMUSG0000003447118
Mib1 / Q80SY4 / E3 ubiquitin-protein ligase MIB1 / Q86YT6* / mindbomb E3 ubiquitin protein ligase 1*ENSMUSG000000242949
Mib2 / Q8R516 / E3 ubiquitin-protein ligase MIB2 / Q96AX9* / mindbomb E3 ubiquitin protein ligase 2*ENSMUSG000000290608
Ankrd6 / Q69ZU8 / Mus musculus ankyrin repeat domain 6 (Ankrd6), transcript variant 4, mRNA. / Q9Y2G4* / ankyrin repeat domain 6*ENSMUSG000000401837
Q14DN9 / Ankdd1b / Ankyrin repeat and death domain-containing protein 1B / A6NHY2* / ankyrin repeat and death domain containing 1B*ENSMUSG000000471176
Ankdd1a / ankyrin repeat and death domain containing 1A / Q495B1*ENSMUSG000000665105


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR033635  Ankyrin repeat and SAM domain-containing protein 1
 IPR033636  Ankyrin repeat and SAM domain-containing protein 1B
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1900383 regulation of synaptic plasticity by receptor localization to synapse IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rrm1tm1.1Ofc/Rrm1tm1.1Ofc,Tg(CAG-Rrm2)#Rsw/Tg(CAG-Rrm2)#Rsw
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rrm1tm1.1Ofc/Rrm1tm1.1Ofc,Tg(CAG-Rrm2)#Rsw/Tg(CAG-Rrm2)#Rsw
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0011274 short excitatory postsynaptic current decay time 
Show

Allelic Composition: Rrm1tm1.1Ofc/Rrm1tm1.1Ofc,Tg(CAG-Rrm2)#Rsw/Tg(CAG-Rrm2)#Rsw
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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