ENSMUSG00000033597


Mus musculus

Features
Gene ID: ENSMUSG00000033597
  
Biological name :Caskin1
  
Synonyms : Caskin1 / Q6P9K8
  
Possible biological names infered from orthology : CASK interacting protein 1 / Q8WXD9
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24488783
Gene end: 24508905
  
Corresponding Affymetrix probe sets: 10442468 (MoGene1.0st)   1431338_at (Mouse Genome 430 2.0 Array)   1455397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024958
NCBI entrez gene - 268932     See in Manteia.
MGI - MGI:2442952
RefSeq - XM_006524315
RefSeq - NM_027937
RefSeq - XM_006524313
RefSeq - XM_006524314
RefSeq Peptide - NP_082213
swissprot - Q6P9K8
Ensembl - ENSMUSG00000033597
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 caskin1ENSDARG00000046107Danio rerio
 si:dkeyp-9d4.3ENSDARG00000100166Danio rerio
 ENSGALG00000005844Gallus gallus
 ENSGALG00000030169Gallus gallus
 Q8WXD9ENSG00000167971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHK1 / Caskin2 / Q8WXE0* / CASK interacting protein 2*ENSMUSG0000003447139
Anks1 / P59672 / Ankyrin repeat and SAM domain-containing protein 1A / Q92625* / ANKS1A* / ankyrin repeat and sterile alpha motif domain containing 1A*ENSMUSG0000002421918
Ankrd6 / Q69ZU8 / Mus musculus ankyrin repeat domain 6 (Ankrd6), transcript variant 4, mRNA. / Q9Y2G4* / ankyrin repeat domain 6*ENSMUSG0000004018310
Mib1 / Q80SY4 / E3 ubiquitin-protein ligase MIB1 / Q86YT6* / mindbomb E3 ubiquitin protein ligase 1*ENSMUSG000000242949
Mib2 / Q8R516 / E3 ubiquitin-protein ligase MIB2 / Q96AX9* / mindbomb E3 ubiquitin protein ligase 2*ENSMUSG000000290609
Ankdd1a / ankyrin repeat and death domain containing 1A / Q495B1*ENSMUSG000000665108
Q14DN9 / Ankdd1b / Ankyrin repeat and death domain-containing protein 1B / A6NHY2* / ankyrin repeat and death domain containing 1B*ENSMUSG000000471177
Anks1b / ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 6 / Q7Z6G8* / ankyrin repeat and sterile alpha motif domain containing 1B*ENSMUSG000000585897


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR027013  Caskin-1
 IPR032117  Caskin, C-terminal
 IPR032232  Caskin-1, CASK-interaction domain
 IPR035495  Caskin-1, SH3 domain
 IPR035497  Caskin1/2, SAM repeat 1
 IPR035498  Caskin1/2, SAM repeat 2
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011625 cystolithiasis "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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