ENSMUSG00000024294


Mus musculus

Features
Gene ID: ENSMUSG00000024294
  
Biological name :Mib1
  
Synonyms : E3 ubiquitin-protein ligase MIB1 / Mib1 / Q80SY4
  
Possible biological names infered from orthology : mindbomb E3 ubiquitin protein ligase 1 / Q86YT6
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 10725548
Gene end: 10818704
  
Corresponding Affymetrix probe sets: 10453830 (MoGene1.0st)   1433853_at (Mouse Genome 430 2.0 Array)   1451818_at (Mouse Genome 430 2.0 Array)   1454740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054428
Ensembl peptide - ENSMUSP00000114289
Ensembl peptide - ENSMUSP00000122879
Ensembl peptide - ENSMUSP00000131712
NCBI entrez gene - 225164     See in Manteia.
MGI - MGI:2443157
RefSeq - XM_006525811
RefSeq - NM_144860
RefSeq - XM_006525810
RefSeq Peptide - NP_659109
swissprot - Q80SY4
swissprot - F6ZBL2
swissprot - F6YFW9
Ensembl - ENSMUSG00000024294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mib1ENSDARG00000102184Danio rerio
 MIB1ENSGALG00000014974Gallus gallus
 MIB1ENSG00000101752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mib2 / Q8R516 / E3 ubiquitin-protein ligase MIB2 / Q96AX9* / mindbomb E3 ubiquitin protein ligase 2*ENSMUSG0000002906037
Q8VHK1 / Caskin2 / Q8WXE0* / CASK interacting protein 2*ENSMUSG0000003447112
Q6P9K8 / Caskin1 / Q8WXD9* / CASK interacting protein 1*ENSMUSG0000003359712
Anks1 / P59672 / Ankyrin repeat and SAM domain-containing protein 1A / Q92625* / ANKS1A* / ankyrin repeat and sterile alpha motif domain containing 1A*ENSMUSG0000002421912
Ankdd1a / ankyrin repeat and death domain containing 1A / Q495B1*ENSMUSG0000006651010
Ankrd6 / Q69ZU8 / Mus musculus ankyrin repeat domain 6 (Ankrd6), transcript variant 4, mRNA. / Q9Y2G4* / ankyrin repeat domain 6*ENSMUSG0000004018310
Q14DN9 / Ankdd1b / Ankyrin repeat and death domain-containing protein 1B / A6NHY2* / ankyrin repeat and death domain containing 1B*ENSMUSG000000471179
Anks1b / ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 6 / Q7Z6G8* / ankyrin repeat and sterile alpha motif domain containing 1B*ENSMUSG000000585895


Protein motifs (from Interpro)
Interpro ID Name
 IPR000433  Zinc finger, ZZ-type
 IPR001841  Zinc finger, RING-type
 IPR002110  Ankyrin repeat
 IPR010606  Mib-herc2
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017066  E3 ubiquitin-protein ligase BOI-like
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037252  Mib/herc2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045807 positive regulation of endocytosis IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000262 poor arterial differentiation "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Mib1tm1Kong/Mib1tm1Kong,Mib2tm1Kong/Mib2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm1Kong/Mib1tm1Kong,Mib2tm1Kong/Mib2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurl1atm1Ynj/Neurl1atm1Ynj,Neurl2tm1Kong/Neurl2tm1Kong
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mib1tm1Kong/Mib1tm1Kong,Mib2tm1Kong/Mib2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm1Kong/Mib1+,Mib2tm1Kong/Mib2tm1Kong
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong,Mib2tm1Kong/Mib2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009163 absent pancreatic duct "absence of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Mib1tm1Art/Mib1tm1Art
Genetic Background: BTNTTFArt.129S-Mib1tm1Art

Allelic Composition: Mib1tm2Kong/Mib1tm2Kong,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0012254 absent intersomitic vessels "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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