ENSG00000198646


Homo sapiens

Features
Gene ID: ENSG00000198646
  
Biological name :NCOA6
  
Synonyms : NCOA6 / nuclear receptor coactivator 6 / Q14686
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 34689097
Gene end: 34825649
  
Corresponding Affymetrix probe sets: 1568874_at (Human Genome U133 Plus 2.0 Array)   208979_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351894
Ensembl peptide - ENSP00000481177
Ensembl peptide - ENSP00000481935
Ensembl peptide - ENSP00000486894
Ensembl peptide - ENSP00000363929
NCBI entrez gene - 23054     See in Manteia.
OMIM - 605299
RefSeq - XM_017027751
RefSeq - XM_017027744
RefSeq - XM_017027745
RefSeq - XM_017027746
RefSeq - XM_017027747
RefSeq - XM_017027748
RefSeq - XM_017027749
RefSeq - XM_017027750
RefSeq - NM_001242539
RefSeq - NM_001318240
RefSeq - NM_014071
RefSeq - XM_006723755
RefSeq - XM_011528721
RefSeq - XM_011528726
RefSeq - XM_011528727
RefSeq - XM_017027739
RefSeq - XM_017027740
RefSeq - XM_017027741
RefSeq - XM_017027742
RefSeq - XM_017027743
RefSeq Peptide - NP_054790
RefSeq Peptide - NP_001229468
RefSeq Peptide - NP_001305169
swissprot - A0A0D9SFT8
swissprot - Q14686
swissprot - F6M2K4
swissprot - F6M2K2
Ensembl - ENSG00000198646
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa6ENSDARG00000071272Danio rerio
 NCOA6ENSGALG00000001182Gallus gallus
 Ncoa6ENSMUSG00000038369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR032715  Nuclear receptor coactivator 6, putative nucleic acid-binding region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication NAS
 biological_processGO:0006281 DNA repair NAS
 biological_processGO:0006310 DNA recombination NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0009725 response to hormone TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030099 myeloid cell differentiation IDA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway NAS
 biological_processGO:0042921 glucocorticoid receptor signaling pathway NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030331 estrogen receptor binding TAS
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IPI
 molecular_functionGO:0046965 retinoid X receptor binding TAS
 molecular_functionGO:0046966 thyroid hormone receptor binding IDA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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