Manteia - Molecule gene

ENSMUSG00000038369

Mus musculus

Features

Gene ID:	ENSMUSG00000038369

Biological name :	Ncoa6

Synonyms :	Ncoa6 / nuclear receptor coactivator 6 isoform 2

Possible biological names infered from orthology :	nuclear receptor coactivator 6 / Q14686

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	H1
Gene start:	155390656
Gene end:	155473894

Corresponding Affymetrix probe sets:	10488844 (MoGene1.0st) 1423374_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000118113 Ensembl peptide - ENSMUSP00000045386 Ensembl peptide - ENSMUSP00000105294 Ensembl peptide - ENSMUSP00000105295 NCBI entrez gene - 56406 See in Manteia. MGI - MGI:1929915 RefSeq - XM_011239709 RefSeq - NM_001242558 RefSeq - NM_019825 RefSeq - XM_006499927 RefSeq - XM_006499928 RefSeq - XM_011239708 RefSeq Peptide - NP_001229487 RefSeq Peptide - NP_062799 swissprot - A2AQN0 swissprot - Q5XJV5 swissprot - A2AQM9 Ensembl - ENSMUSG00000038369

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ncoa6	ENSDARG00000071272	Danio rerio
NCOA6	ENSGALG00000001182	Gallus gallus
NCOA6	ENSG00000198646	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR032715	Nuclear receptor coactivator 6, putative nucleic acid-binding region

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006352	DNA-templated transcription, initiation	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0030099	myeloid cell differentiation	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:1903506	regulation of nucleic acid-templated transcription	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0035097	histone methyltransferase complex	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0003713	transcription coactivator activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0030374	nuclear receptor transcription coactivator activity	IEA
molecular_function	GO:0046966	thyroid hormone receptor binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Tcf3^tm1Wein/Tcf3⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Tcf3^tm1Wein/Tcf3⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000295	poorly developed ventricular trabeculae	"retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000565	oligodactyly	"congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Tcf3^tm1Wein/Tcf3⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000596	abnormal liver development	"anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tcf3^tm1Wein/Tcf3⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0000606	decreased hepatocyte number	"fewer than normal number of parenchymal liver cells" [J:23170]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0000628	abnormal mammary gland development	"aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000662	abnormal branching of the mammary ductal tree	"anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Tcf3^tm1Wein/Tcf3⁺ Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Cryaa-NCOA6)AD5Cve/0 Genetic Background:* involves: 129S7/SvEvBrd * FVB/N Allelic Composition: Ncoa6^tm3.1Jxu/Ncoa6^tm3.1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Cryaa-NCOA6)AD5Cve/0 Genetic Background:* involves: 129S7/SvEvBrd * FVB/N Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Tg(Pax6-cre,GFP)1Pgr/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Ncoa6^tm3.1Jxu/Ncoa6^tm3.1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Cryaa-NCOA6)AD5Cve/0 Genetic Background:* involves: 129S7/SvEvBrd * FVB/N Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Tg(Pax6-cre,GFP)1Pgr/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Ncoa6^tm3.1Jxu/Ncoa6^tm3.1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Ncoa6^tm3.1Jxu/Ncoa6⁺,Tg(Cryaa-NCOA6)AD5Cve/0 Genetic Background:* involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001324	abnormal eye pigmentation	"change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001711	abnormal placenta		Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001712	abnormal placental development	"malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001792	impaired wound healing	"reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001889	delayed brain development	"the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Orai1^tm1Rao/Orai1^tm1Rao Genetic Background: involves: C57BL/6NTac * ICR
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0002190	disorganized myocardium	"malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0002740	heart hypoplasia	"decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002908	delayed wound healing	"longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0003057	abnormal epicardium morphology	"anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003231	abnormal placental vasculature	"malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003396	abnormal embryonic hematopoiesis	"anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003403	absent placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003451	absent olfactory bulb	"absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0003567	abnormal cardiomyocyte proliferation	"anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003845	abnormal decidualization	"disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]	Show Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003868	abnormal feces composition	"increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0004057	thin myocardial compact layer	"reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0004255	abnormal spongiotrophoblast layer morphology	"anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0004938	dilated vasculature	"stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0005031	abnormal trophoblast	"malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0005365	abnormal bile salt homeostasis	"anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]	Show Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb^tm5Sor Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0006270	abnormal mammary gland growth during lactation	"anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0006372	impaired placental function	"reduction in the ability of the placenta to supply nutrients or remove waste" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0008788	abnormal fetal cardiomyocyte morphology	"any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1 Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0008959	abnormal spongiotrophoblast cell morphology	"any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0009397	increased trophoblast giant cell number	"greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009662	abnormal uterine receptivity	"any alteration in the time sensitive process of uterine differentiation that occurs in response to implantation competent blastocysts and precedes and is necessary for embryo implantation" [PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009664	abnormal luminal closure	"an anomaly in the degree to which (for each species) the uterine epithelium closes over and makes contact with, and secures an implanting blastocyst" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Ncoa6^tm3Jxu/Ncoa6^tm3Jxu,Pgr^tm2(cre)Lyd/Pgr⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009887	abnormal palatal shelf fusion at midline	"any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Jxu/Ncoa6^tm1Jxu Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Kiss1r^{tm1.1(KOMP)Vlcg}/Kiss1r^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Kiss1r^{tm1.1(KOMP)Vlcg}/Ucd
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0012099	decreased spongiotrophoblast size	"reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1
MP:0012235	abnormal liver bud morphology	"any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]	Show Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0013191	increased sebaceous gland number	"greater than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [MGI:anna]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Ncoa6^tm1Hhs/Ncoa6⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0013501	increased fibroblast apoptosis	"increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Ncoa6^tm1Hhs/Ncoa6^tm1Hhs Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
MP:0013716	hypolactation	"partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0013782	abnormal mammary duct terminal end bud morphology	"any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [MGI:Anna, PMID:16280048, PMID:16916375, PMID:18296651]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺,Nf1^tm1Par/Nf1^tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0020527	small thalamus	"decreased size of the thalamus" [MGI:smb]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj,Tsg101^tm1Mak/Tsg101^tm1Mak Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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