ENSG00000204394


Homo sapiens

Features
Gene ID: ENSG00000204394
  
Biological name :VARS
  
Synonyms : P26640 / valyl-tRNA synthetase / VARS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31777518
Gene end: 31795953
  
Corresponding Affymetrix probe sets: 201796_s_at (Human Genome U133 Plus 2.0 Array)   201797_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413925
Ensembl peptide - ENSP00000415679
Ensembl peptide - ENSP00000364815
NCBI entrez gene - 7407     See in Manteia.
OMIM - 192150
RefSeq - XM_017011247
RefSeq - NM_006295
RefSeq - XM_005249362
RefSeq - XM_017011246
RefSeq Peptide - NP_006286
swissprot - P26640
swissprot - A2ABF4
swissprot - H0Y426
swissprot - A0A024RCN6
Ensembl - ENSG00000204394
  
Related genetic diseases (OMIM): 617802 - Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy, 617802
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 varsENSDARG00000044575Danio rerio
 VarsENSMUSG00000007029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VARS2 / Q5ST30 / valyl-tRNA synthetase 2, mitochondrialENSG0000013741140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002300  Aminoacyl-tRNA synthetase, class Ia
 IPR002303  Valine-tRNA ligase
 IPR004046  Glutathione S-transferase, C-terminal
 IPR009008  Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
 IPR009080  Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR013155  Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR033705  Valyl tRNA synthetase, anticodon-binding domain
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily
 IPR037118  Valyl-tRNA synthetase, tRNA-binding arm superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006438 valyl-tRNA aminoacylation IEA
 biological_processGO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002161 aminoacyl-tRNA editing activity IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004832 valine-tRNA ligase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Cytosolic tRNA aminoacylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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