ENSG00000205542


Homo sapiens

Features
Gene ID: ENSG00000205542
  
Biological name :TMSB4X
  
Synonyms : P62328 / thymosin beta 4, X-linked / TMSB4X
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 12975108
Gene end: 12977227
  
Corresponding Affymetrix probe sets: 216438_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370010
Ensembl peptide - ENSP00000414376
Ensembl peptide - ENSP00000370007
Ensembl peptide - ENSP00000370009
NCBI entrez gene - 7114     See in Manteia.
OMIM - 300159
RefSeq - NM_021109
RefSeq Peptide - NP_066932
swissprot - A2VCK8
swissprot - P62328
Ensembl - ENSG00000205542
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmsb4xENSDARG00000077777Danio rerio
 ENSGALG00000026383Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14604 / TMSB4Y / thymosin beta 4, Y-linkedENSG0000015462093
P63313 / TMSB10 / thymosin beta 10ENSG0000003451075
P0CG35 / TMSB15B / thymosin beta 15BENSG0000015842770
P0CG34 / TMSB15A / thymosin beta 15aENSG0000015816470
TMSB15B / thymosin beta 15BENSG0000026922670


Protein motifs (from Interpro)
Interpro ID Name
 IPR001152  Beta-thymosin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007253 cytoplasmic sequestering of NF-kappaB IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0042989 sequestering of actin monomers IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IGI
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
 biological_processGO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism IDA
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IDA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IDA
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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