ENSG00000214253


Homo sapiens

Features
Gene ID: ENSG00000214253
  
Biological name :FIS1
  
Synonyms : FIS1 / fission, mitochondrial 1 / Q9Y3D6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 101239458
Gene end: 101252316
  
Corresponding Affymetrix probe sets: 218034_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413500
Ensembl peptide - ENSP00000444771
Ensembl peptide - ENSP00000442056
Ensembl peptide - ENSP00000223136
Ensembl peptide - ENSP00000395964
Ensembl peptide - ENSP00000411442
NCBI entrez gene - 51024     See in Manteia.
OMIM - 609003
RefSeq - NM_016068
RefSeq Peptide - NP_057152
swissprot - F8WBT1
swissprot - F8WD11
swissprot - C9JXH1
swissprot - Q9Y3D6
swissprot - F5H509
swissprot - F5H8A8
Ensembl - ENSG00000214253
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fis1ENSDARG00000114549Danio rerio
 Fis1ENSMUSG00000019054Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR016543  Mitochondria fission 1 protein
 IPR028058  Fis1, N-terminal tetratricopeptide repeat
 IPR028061  Fis1, C-terminal tetratricopeptide repeat
 IPR033745  Mitochondria fission protein Fis1, cytosolic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IMP
 biological_processGO:0000422 autophagy of mitochondrion IDA
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0006626 protein targeting to mitochondrion IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0008053 mitochondrial fusion IMP
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016559 peroxisome fission IMP
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071396 cellular response to lipid IEA
 biological_processGO:0090141 positive regulation of mitochondrial fission IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IDA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1904579 cellular response to thapsigargin IEA
 biological_processGO:1905395 response to flavonoid IEA
 biological_processGO:1990910 response to hypobaric hypoxia IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome ISS
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005779 integral component of peroxisomal membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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