ENSG00000254999


Homo sapiens

Features
Gene ID: ENSG00000254999
  
Biological name :BRK1
  
Synonyms : BRICK1, SCAR/WAVE actin nucleating complex subunit / BRK1 / Q8WUW1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p25.3
Gene start: 10115592
Gene end: 10127190
  
Corresponding Affymetrix probe sets: 224023_s_at (Human Genome U133 Plus 2.0 Array)   224575_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432472
NCBI entrez gene - 55845     See in Manteia.
OMIM - 611183
RefSeq - NM_018462
RefSeq Peptide - NP_060932
swissprot - Q8WUW1
Ensembl - ENSG00000254999
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brk1ENSDARG00000041974Danio rerio
 BRK1ENSGALG00000038941Gallus gallus
 Brk1ENSMUSG00000033940Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033378  Protein BRICK1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IMP
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0070207 protein homotrimerization IDA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031209 SCAR complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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