ENSMUSG00000033940


Mus musculus

Features
Gene ID: ENSMUSG00000033940
  
Biological name :Brk1
  
Synonyms : Brk1 / Protein BRICK1 / Q91VR8
  
Possible biological names infered from orthology : BRICK1, SCAR/WAVE actin nucleating complex subunit / Q8WUW1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113604772
Gene end: 113616951
  
Corresponding Affymetrix probe sets: 10540785 (MoGene1.0st)   1423188_a_at (Mouse Genome 430 2.0 Array)   1423189_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041644
NCBI entrez gene - 101314     See in Manteia.
MGI - MGI:1915406
RefSeq - NM_133937
RefSeq Peptide - NP_598698
swissprot - Q91VR8
Ensembl - ENSMUSG00000033940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brk1ENSDARG00000041974Danio rerio
 BRK1ENSGALG00000038941Gallus gallus
 BRK1ENSG00000254999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033378  Protein BRICK1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IBA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0048870 cell motility IMP
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0031209 SCAR complex IBA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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