ENSG00000272886


Homo sapiens

Features
Gene ID: ENSG00000272886
  
Biological name :DCP1A
  
Synonyms : DCP1A / decapping mRNA 1A / Q9NPI6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.1
Gene start: 53283428
Gene end: 53347610
  
Corresponding Affymetrix probe sets: 218508_at (Human Genome U133 Plus 2.0 Array)   225443_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480912
Ensembl peptide - ENSP00000476046
Ensembl peptide - ENSP00000476386
Ensembl peptide - ENSP00000477594
Ensembl peptide - ENSP00000479387
NCBI entrez gene - 55802     See in Manteia.
OMIM - 607010
RefSeq - NM_001290204
RefSeq - NM_001290205
RefSeq - NM_001290206
RefSeq - NM_001290207
RefSeq - NM_018403
RefSeq Peptide - NP_001277135
RefSeq Peptide - NP_060873
RefSeq Peptide - NP_001277133
RefSeq Peptide - NP_001277134
RefSeq Peptide - NP_001277136
swissprot - A0A087WXD0
swissprot - Q9NPI6
swissprot - A0A087WVE6
swissprot - A0A087WT55
Ensembl - ENSG00000272886
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcp1aENSDARG00000100136Danio rerio
 ENSGALG00000041547Gallus gallus
 Dcp1aENSMUSG00000021962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DCP1B / Q8IZD4 / decapping mRNA 1BENSG0000015106528


Protein motifs (from Interpro)
Interpro ID Name
 IPR010334  mRNA-decapping enzyme subunit 1
 IPR011993  PH-like domain superfamily
 IPR031953  mRNA-decapping enzyme, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
 biological_processGO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IMP
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030234 enzyme regulator activity IBA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
mRNA decay by 5 to 3 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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