ENSGALG00000004057


Gallus gallus

Features
Gene ID: ENSGALG00000004057
  
Biological name :HMGCL
  
Synonyms : HMGCL / hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 4
  
Possible biological names infered from orthology : 3-hydroxymethyl-3-methylglutaryl-CoA lyase / Hydroxymethylglutaryl-CoA lyase, mitochondrial / P35914 / P38060
  
Species: Gallus gallus
  
Chr. number: 23
Strand: -1
Band:
Gene start: 5610015
Gene end: 5613638
  
Corresponding Affymetrix probe sets: Gga.2537.1.S1_at (Chicken Array)   Gga.2537.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000034301
Ensembl peptide - ENSGALP00000064589
Ensembl peptide - ENSGALP00000058817
Ensembl peptide - ENSGALP00000056883
Ensembl peptide - ENSGALP00000044100
Ensembl peptide - ENSGALP00000006445
NCBI entrez gene - 396316     See in Manteia.
RefSeq - NM_001198714
RefSeq - NM_001198717
RefSeq - NM_001198716
RefSeq - NM_001198715
RefSeq Peptide - NP_001185646
RefSeq Peptide - NP_001185643
RefSeq Peptide - NP_001185644
RefSeq Peptide - NP_001185645
swissprot - A0A1D5PVB9
swissprot - A0A1L1RJ90
swissprot - A0A1L1S0F6
swissprot - F1P1E7
swissprot - F1NWD1
swissprot - A0A1D5NUT2
Ensembl - ENSGALG00000004057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgclENSDARG00000021220Danio rerio
 HMGCLENSG00000117305Homo sapiens
 HmgclENSMUSG00000028672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGCLL1 / 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 / Q8JZS7* / Q8TB92* / 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic *ENSGALG0000001629470


Protein motifs (from Interpro)
Interpro ID Name
 IPR000138  Hydroxymethylglutaryl-CoA lyase, active site
 IPR000891  Pyruvate carboxyltransferase
 IPR013785  Aldolase-type TIM barrel
 IPR030020  Hydroxymethylglutaryl-CoA lyase, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0046951 ketone body biosynthetic process IEA
 biological_processGO:0051262 protein tetramerization IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004419 hydroxymethylglutaryl-CoA lyase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of Ketone Bodies
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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