ENSGALG00000007706


Gallus gallus

Features
Gene ID: ENSGALG00000007706
  
Biological name :FGF8
  
Synonyms : FGF8 / fibroblast growth factor 8 precursor
  
Possible biological names infered from orthology : fibroblast growth factor 8 / P37237 / P55075
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 22705280
Gene end: 22715778
  
Corresponding Affymetrix probe sets: Gga.17369.1.S1_at (Chicken Array)   Gga.661.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046521
Ensembl peptide - ENSGALP00000032574
NCBI entrez gene - 396313     See in Manteia.
RefSeq - XM_015288595
RefSeq - NM_001012767
RefSeq Peptide - NP_001012785
swissprot - Q4R0X9
swissprot - A0A1D5P1I3
Ensembl - ENSGALG00000007706
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF8ENSG00000107831Homo sapiens
 Fgf8ENSMUSG00000025219Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF18 / fibroblast growth factor 18 / O76093* / O89101*ENSGALG0000000220344


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028249  Fibroblast growth factor 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IEA
 biological_processGO:0001839 neural plate morphogenesis IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008078 mesodermal cell migration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008406 gonad development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEA
 biological_processGO:0009880 embryonic pattern specification IDA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021543 pallium development IEA
 biological_processGO:0021544 subpallium development IEA
 biological_processGO:0021798 forebrain dorsal/ventral pattern formation IEA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0030916 otic vesicle formation IEA
 biological_processGO:0030917 midbrain-hindbrain boundary development IEA
 biological_processGO:0035050 embryonic heart tube development IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035909 aorta morphogenesis IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048699 generation of neurons IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055026 negative regulation of cardiac muscle tissue development IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060128 corticotropin hormone secreting cell differentiation IEA
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IEA
 biological_processGO:0060173 limb development IDA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0060563 neuroepithelial cell differentiation IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling NAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0071774 response to fibroblast growth factor IMP
 biological_processGO:0090134 cell migration involved in mesendoderm migration IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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