Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
MP:0000270	abnormal heart tube morphology	"malformed embryonic heart " [J:37888]	Show Allelic Composition: Dad1^tm1Brw/Dad1^tm1Brw Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Tg(Mef2c-cre)2Blk/0 Genetic Background: Not Specified Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dad1^tm1Brw/Dad1^tm1Brw Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000455	abnormal maxilla morphology	"malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000551	absent forelimb	"missing the entire anterior extremities" [MGI:tc, J:54637]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000553	absent radius	"missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000557	absent hindlimb	"missing the entire posterior extremities" [MGI:tc, J:54637]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd
MP:0000565	oligodactyly	"congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0000633	abnormal pituitary gland morphology	"anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd
MP:0000678	abnormal parathyroid gland morphology	"anomalous structure of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0000680	absent parathyroid glands	"missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0000704	abnormal thymus development	"anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0000836	abnormal substantia nigra morphology	"malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0000850	absent cerebellum	"missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0000864	abnormal vermis	"malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Fgf17^tm1Dor/Fgf17^tm1Dor Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0000867	abnormal anterior vermis	"malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Fgf17^tm1Dor/Fgf17^tm1Dor Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: Fgf17^tm1Dor/Fgf17^tm1Dor,Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: 129S6/SvEvTac
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cd80^tm1Lbgn/Cd80^tm1Lbgn Genetic Background: C3.Cg-Cd80^tm1Lbgn
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0000933	abnormal rhombomere morphology	"malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Aicda^tm1Hon/Aicda^tm1Hon,Ighm^{tm1.1(IGH-2)Cog}/Ighm⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
MP:0000936	small telencephalic vesicles	"reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0001065	abnormal trigeminal nerve morphology	"malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: Fgf8^tm2.1Jyhl/Fgf8⁺ Genetic Background: B6.129S6-Fgf8^tm2.1Jyhl
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: cir/cir⁺,Tmie^sr/Tmie⁺ Genetic Background: involves: C57BL/6J * C57BL/How * ICR
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Cd80^tm1Lbgn/Cd80^tm1Lbgn Genetic Background: C3.Cg-Cd80^tm1Lbgn
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0001675	abnormal ectoderm development	"failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1 Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0001726	abnormal allantois	"malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: cir/cir⁺,Tmie^sr/Tmie⁺ Genetic Background: involves: C57BL/6J * C57BL/How * ICR
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Dad1^tm1Brw/Dad1^tm1Brw Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm2Mrc/Fgf8^tm2Mrc Genetic Background: Not Specified
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm2Mrc/Fgf8^tm2Mrc Genetic Background: Not Specified
MP:0002115	abnormal skeleton extremities morphology	"abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm2Mrc/Fgf8^tm2Mrc Genetic Background: Not Specified
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aicda^tm1Hon/Aicda^tm1Hon,Ighm^{tm1.1(IGH-2)Cog}/Ighm⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0002160	abnormal reproductive system morphology	"structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: cir/cir⁺,Tmie^sr/Tmie⁺ Genetic Background: involves: C57BL/6J * C57BL/How * ICR
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc Genetic Background: Not Specified Allelic Composition: Fgf8^tm2Mrc/Fgf8^tm2Mrc Genetic Background: Not Specified Allelic Composition: Fgf8^tm1(cre)Itl/Fgf8⁺ Genetic Background: Not Specified
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1 Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002836	abnormal chorion	"malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0002925	abnormal cardiovascular development	"aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002950	abnormal neural crest cell migration	"defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0003007	ectopic thymus	"ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0003140	dilated atria	"an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003152	abnormal pillar cell differentiation	"abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [J:32991, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0003202	abnormal neuron apoptosis	"change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hey2^tm1Mtc/Hey2^tm1Mtc Genetic Background: C.Cg-Hey2^tm1Mtc
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Hey2^tm1Mtc/Hey2^tm1Mtc Genetic Background: C.Cg-Hey2^tm1Mtc Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.4Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003204	decreased neuron apoptosis	"decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Airn^tm1Dpb/Airn⁺ Genetic Background: involves: FVB/N
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003395	abnormal subclavian artery morphology	"malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0003451	absent olfactory bulb	"absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0003494	parathyroid hypoplasia		Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0003649	reduced right ventricle		Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003854	abnormal forelimb stylopod morphology		Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003855	abnormal forelimb zeugopod morphology		Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003856	abnormal hindlimb stylopod morphology		Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003857	abnormal hindlimb zeugopod morphology		Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003872	absent right ventricle	"missing the lower right chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003873	branchial arch hypoplasia	"reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003877	abnormal serotonergic neuron morphology	"malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0003920	abnormal right ventricle morphology	"structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0003931	absent molars	"missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0004044	aortic dissection	"a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0004083	polysyndactyly	"greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]	Show Allelic Composition: cir/cir⁺,Tmie^sr/Tmie⁺ Genetic Background: involves: C57BL/6J * C57BL/How * ICR
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Tg(Mef2c-cre)2Blk/0 Genetic Background: Not Specified
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0004113	abnormal aortic arch morphology	"structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^{tm4(cre/Esr1)Bld}/Tbx1⁺ Genetic Background:* involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tbx1^{tm4(cre/Esr1)Bld}/Tbx1⁺ Genetic Background:* involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8⁺,Tbx1^{tm4(cre/Esr1)Bld}/Tbx1⁺ Genetic Background:* involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Fgf8^tm1.3Mrt/Fgf8⁺,Six1^{tm1(cre,ALPP)Xli}/Six1⁺ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0004160	retroesophageal right subclavian artery	"the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004161	cervical aortic arch	"aortic arch is located above the level of the clavicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR Allelic Composition: Fgf8^tm1.3Mrt/Fgf8⁺,Six1^{tm1(cre,ALPP)Xli}/Six1⁺ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0004312	absent pillar cells	"absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004318	absent incus	"absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0004439	absent Meckel s cartilage	"absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0004575	small limb buds	"reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004592	small mandible	"reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004759	decreased mitotic index	"decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd
MP:0004837	abnormal neural fold formation	"any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1
MP:0004861	abnormal Raphe nucleus morphology	"any structural anomaly of the subgroup of the reticular nuclei of the brain stem that are located in and along the median plane of the medulla oblongata, pons, and mesencephalon that include neurons that synthesize serotonin and extend ascending fibers to parts of the limbic system and descending fibers to other brain stem nuclei, the medulla oblongata, and the pons" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0005029	abnormal amnion	"malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0005221	abnormal rostral-caudal axis patterning	"anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: cir/cir⁺,Tmie^sr/Tmie⁺ Genetic Background: involves: C57BL/6J * C57BL/How * ICR
MP:0006032	abnormal ureteric bud morphology	"anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 Allelic Composition: Fgf8^tm1.3Mrt/Fgf8⁺,Six1^{tm1(cre,ALPP)Xli}/Six1⁺ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006279	abnormal limb development	"anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(CAG-Bgeo,-Fgf4)1Mrt/?,Tg(Msx2-cre)5Rem/? Genetic Background: involves: 129P2/OlaHsd
MP:0006280	abnormal digit development	"anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(CAG-Bgeo,-Fgf4)1Mrt/?,Tg(Msx2-cre)5Rem/? Genetic Background: involves: 129P2/OlaHsd
MP:0006306	abnormal nasal pit morphology	"malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tfap2a^tm1Will/Tfap2a^tm2.1Will Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ripk2^tm1Flv/Ripk2^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8⁺,Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0006331	abnormal patterning of the organ of Corti	"anomaly in the organization of the various cell types within the organ of Corti into a set number of distinct rows" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0006341	small first branchial arch	"reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0006346	small branchial arch	"reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0006354	abnormal fourth branchial arch artery morphology	"any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Fgf8^tm1.2Mrt/Fgf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006355	abnormal sixth branchial arch artery morphology	"any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006356	abnormal third branchial arch artery morphology	"any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0006386	absent somites	"missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0008825	abnormal cardiac epithelial to mesenchymal transition	"anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0008919	fused tarsal bones	"anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(CAG-Bgeo,-Fgf4)1Mrt/?,Tg(Msx2-cre)5Rem/? Genetic Background: involves: 129P2/OlaHsd
MP:0009038	decreased inferior colliculus size	"decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Fgf17^tm1Dor/Fgf17^tm1Dor Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: Fgf17^tm1Dor/Fgf17^tm1Dor,Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: 129S6/SvEvTac
MP:0009039	absent inferior colliculus	"absence of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Gli3^tm1.1Alj/Gli3^tm1.1Alj Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0009048	enlarged tectum	"increased size of the rostral part of the midbrain roof" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Gli3^tm1.1Alj/Gli3^tm1.1Alj Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0009331	absent primitive node	"absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl Genetic Background: involves: CD-1
MP:0009844	abnormal neural crest cell apoptosis	"change in the timing or the number of neural crest cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0009845	abnormal neural crest cell morphology	"any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd
MP:0009893	cleft primary palate	"congenital fissure of the tissues normally uniting to form the primary palate" [PMID:16680722]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tfap2a^tm1Will/Tfap2a^tm2.1Will Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss
MP:0009907	decreased tongue size	"reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010241	abnormal aortic arch development	"anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0010406	absent atrial septum	"absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0010432	common ventricle	"the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0010454	abnormal truncus arteriosis septation	"anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0010465	aberrant origin of the right subclavian artery	"the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0010527	bicuspid pulmonary valve	"the presence of two cusps or leaflets in the pulmonary valve instead of three" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0010585	abnormal conotruncal ridge morphology	"any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm2.1Jyhl/Fgf8⁺ Genetic Background: B6.129S6-Fgf8^tm2.1Jyhl
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Tg(Nes-cre)1Atp/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.3Mrt,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1.1Mrt/Fgf8^tm1.2Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Del(19Poll-Fbxw4)4Fsp/+,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc,Isl1^tm1(cre)Sev/Isl1⁺ Genetic Background: involves: 129S/Sv
MP:0011262	abnormal branchial arch mesenchyme morphology	"any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd
MP:0011354	absent renal glomerulus	"complete absence of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit" [ISBN:0-683-40008-8]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0011368	increased kidney apoptosis	"increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
MP:0011388	absent heart	"absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0011448	decreased dopaminergic neuron number	"fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]	Show Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: En1^{tm7(cre/ESR1)Alj}/0,Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8⁺,Fgf9^tm1Dor/Fgf9⁺,Fgfr3^tm1.1Aomw/Fgfr3⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0012179	abnormal splanchnic mesoderm morphology	"any structural abnormality of the inner layer of lateral plate mesoderm, located above (dorsally) the endoderm, which forms the circulatory system and future gut wall" [MGI:anna]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm2Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129 * 129S7/SvEvBrd Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
MP:0012278	abnormal cardiogenic mesoderm morphology	"any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl Genetic Background: involves: CD-1
MP:0012685	abnormal primitive streak elongation	"any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]	Show Allelic Composition: Fgf4^tm1.2Mrt/Fgf4^tm1.3Mrt,Tg(Msx2-cre)5Rem/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.4Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fgf8^tm1.2Mrt/Fgf8^tm1.4Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0012729	abnormal common carotid artery morphology	"any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0012730	abnormal internal carotid artery morphology	"any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Tg(Tbx1-cre)1Joe/0 Genetic Background: Not Specified
MP:0012752	abnormal cardiac neural crest cell migration	"any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013268	second pharyngeal arch hypoplasia	"underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013269	third pharyngeal arch hypoplasia	"underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺ Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
MP:0013574	ectopic parathyroid gland	"a parathyroid gland located outside of its normal position; in the normal adult mouse, the parathyroids are usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; because of their common pharyngeal pouch origin, ectopic thyroid and parathyroid tissue can occasionally be found in the thymus" [MGI:Anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0014044	absent cardiac outflow tract	"absence of or complete failure to form the common arterial trunk that normally forms the aorta and pulmonary artery and the ventricular outflow regions" [MGI:anna]	Show Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0030095	abnormal midface morphology	"any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]	Show Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺,Tfap2a^tm1Will/Tfap2a^tm2.1Will Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss
MP:0030334	absent sixth pharyngeal arch artery	"failure to develop or absence of the sixth pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0030336	third pharyngeal arch artery hypoplasia	"underdevelopment or reduced size of the third pharyngeal arch artery, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm3Mrc Genetic Background: involves: 129/Sv * C57BL/6
MP:0030337	enlarged third pharyngeal arch artery	"increased size of the third pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Hoxa3^tm1(cre)Moon/Hoxa3⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0030340	absent fourth pharyngeal arch artery	"failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0030341	fourth pharyngeal arch artery hypoplasia	"underdevelopment or reduced size of the fourth pharyngeal arch artery, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm1Moon,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129/Sv * C57BL/6

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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