ENSMUSG00000022101


Mus musculus

Features
Gene ID: ENSMUSG00000022101
  
Biological name :Fgf17
  
Synonyms : Fgf17 / Fibroblast growth factor 17 / P63075
  
Possible biological names infered from orthology : O60258
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70636203
Gene end: 70642268
  
Corresponding Affymetrix probe sets: 10421436 (MoGene1.0st)   1421523_at (Mouse Genome 430 2.0 Array)   1456239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022697
Ensembl peptide - ENSMUSP00000154684
NCBI entrez gene - 14171     See in Manteia.
MGI - MGI:1202401
RefSeq - XM_011244953
RefSeq - NM_008004
RefSeq - XM_006518551
RefSeq - XM_006518552
RefSeq Peptide - NP_032030
swissprot - Q0VF19
swissprot - B7ZMS7
swissprot - P63075
Ensembl - ENSMUSG00000022101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf17ENSDARG00000102778Danio rerio
 FGF17ENSG00000158815Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf8 / P37237 / Fibroblast growth factor 8 / P55075*ENSMUSG0000002521957
Fgf18 / O89101 / Fibroblast growth factor 18 / O76093*ENSMUSG0000005796743


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028287  Fibroblast growth factor 17


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005111 type 2 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Fgf17tm1Dor/Fgf17tm1Dor
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Fgf17tm1Dor/Fgf17tm1Dor
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

 MP:0000868 decreased size of anterior vermis "smaller appearance of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Fgf17tm1Dor/Fgf17tm1Dor
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Fgf17tm1Dor/Fgf17tm1Dor
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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