ENSGALG00000010675


Gallus gallus

Features
Gene ID: ENSGALG00000010675
  
Biological name :PSMC1
  
Synonyms : 26S proteasome regulatory subunit 4 / PSMC1
  
Possible biological names infered from orthology : P62191 / P62192 / protease (prosome, macropain) 26S subunit, ATPase 1 / proteasome 26S subunit, ATPase 1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 43855364
Gene end: 43863536
  
Corresponding Affymetrix probe sets: Gga.1071.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059619
Ensembl peptide - ENSGALP00000017347
NCBI entrez gene - 395804     See in Manteia.
RefSeq - NM_204958
RefSeq Peptide - NP_990289
swissprot - F1NSP7
swissprot - A0A1L1RLH7
Ensembl - ENSGALG00000010675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc1aENSDARG00000030537Danio rerio
 psmc1bENSDARG00000043561Danio rerio
 PSMC1ENSG00000100764Homo sapiens
 Psmc1ENSMUSG00000021178Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005838 proteasome regulatory particle IEA
 cellular_componentGO:0022624 proteasome accessory complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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