ENSMUSG00000021178


Mus musculus

Features
Gene ID: ENSMUSG00000021178
  
Biological name :Psmc1
  
Synonyms : P62192 / protease (prosome, macropain) 26S subunit, ATPase 1 / Psmc1
  
Possible biological names infered from orthology : P62191 / proteasome 26S subunit, ATPase 1
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 100110154
Gene end: 100123405
  
Corresponding Affymetrix probe sets: 10397741 (MoGene1.0st)   10439878 (MoGene1.0st)   1416005_at (Mouse Genome 430 2.0 Array)   1439392_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021595
NCBI entrez gene - 19179     See in Manteia.
MGI - MGI:106054
RefSeq - NM_008947
RefSeq Peptide - NP_032973
swissprot - P62192
swissprot - Q542I9
Ensembl - ENSMUSG00000021178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc1aENSDARG00000030537Danio rerio
 psmc1bENSDARG00000043561Danio rerio
 PSMC1ENSGALG00000010675Gallus gallus
 PSMC1ENSG00000100764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035244  26S Proteasome regulatory subunit 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005838 proteasome regulatory particle IDA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 cellular_componentGO:0031597 cytosolic proteasome complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Psmc1tm1Maye/Psmc1tm1.1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Psmc1tm1Maye/Psmc1tm1Maye,Thtm1(cre)Te/Th+
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

 MP:0012508 forebrain atrophy "acquired diminution of the size of the forebrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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