ENSGALG00000030515


Gallus gallus

Features
Gene ID: ENSGALG00000030515
  
Biological name :UBE2N
  
Synonyms : UBE2N / ubiquitin-conjugating enzyme E2 N
  
Possible biological names infered from orthology : P61088 / P61089
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 44841386
Gene end: 44860420
  
Corresponding Affymetrix probe sets: Gga.14435.1.A1_at (Chicken Array)   Gga.14435.1.S1_at (Chicken Array)   Gga.2832.1.S1_at (Chicken Array)   Gga.4470.1.S1_at (Chicken Array)   GgaAffx.20654.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054456
Ensembl peptide - ENSGALP00000064834
Ensembl peptide - ENSGALP00000063826
NCBI entrez gene - 417898     See in Manteia.
RefSeq - NM_001012810
RefSeq Peptide - NP_001012828
swissprot - A0A1L1S122
swissprot - A0A1L1RY95
swissprot - A0A1D5PNL3
Ensembl - ENSGALG00000030515
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2naENSDARG00000008748Danio rerio
 ube2nbENSDARG00000045877Danio rerio
 UBE2NENSG00000177889Homo sapiens
 Ube2nENSMUSG00000074781Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2T / ubiquitin conjugating enzyme E2 T / Q9CQ37* / Q9NPD8*ENSGALG0000000010243


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000729 DNA double-strand break processing IEA
 biological_processGO:0006301 postreplication repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0031058 positive regulation of histone modification IEA
 biological_processGO:0033182 regulation of histone ubiquitination IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031372 UBC13-MMS2 complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035370 UBC13-UEV1A complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
FCERI mediated NF-kB activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IKK complex recruitment mediated by RIP1
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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