ENSMUSG00000074781


Mus musculus

Features
Gene ID: ENSMUSG00000074781
  
Biological name :Ube2n
  
Synonyms : P61089 / Ube2n / ubiquitin-conjugating enzyme E2N
  
Possible biological names infered from orthology : UBE2NL / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 95515145
Gene end: 95545657
  
Corresponding Affymetrix probe sets: 10365918 (MoGene1.0st)   10530759 (MoGene1.0st)   1422559_at (Mouse Genome 430 2.0 Array)   1435384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096932
Ensembl peptide - ENSMUSP00000151850
NCBI entrez gene - 93765     See in Manteia.
MGI - MGI:1934835
RefSeq - NM_080560
RefSeq Peptide - NP_542127
swissprot - A2RTT4
swissprot - A0A1W2P7Z3
swissprot - P61089
Ensembl - ENSMUSG00000074781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2naENSDARG00000008748Danio rerio
 ube2nbENSDARG00000045877Danio rerio
 UBE2NENSGALG00000030515Gallus gallus
 UBE2NLENSG00000276380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2t / Q9CQ37 / ubiquitin-conjugating enzyme E2T / Q9NPD8*ENSMUSG0000002642944


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0000729 DNA double-strand break processing ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006301 postreplication repair ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0016574 histone ubiquitination ISS
 biological_processGO:0031058 positive regulation of histone modification ISO
 biological_processGO:0033182 regulation of histone ubiquitination ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0045739 positive regulation of DNA repair ISS
 biological_processGO:0050852 T cell receptor signaling pathway ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity ISS
 biological_processGO:0070534 protein K63-linked ubiquitination ISO
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031372 UBC13-MMS2 complex ISO
 cellular_componentGO:0035370 UBC13-UEV1A complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IGI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ube2ntm1Aki/Ube2ntm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Umodurehr4/Umodurehr4
Genetic Background: C3HeB/FeJ-Umodurehr4

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Ube2nGt(OST374154)Lex/Ube2n+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ube2ntm1Aki/Ube2ntm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ube2nGt(OST374154)Lex/Ube2n+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ube2nGt(OST374154)Lex/Ube2n+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ube2nGt(OST374154)Lex/Ube2n+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Umodurehr4/Umodurehr4
Genetic Background: C3HeB/FeJ-Umodurehr4

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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