ENSMUSG00000000216


Mus musculus

Features
Gene ID: ENSMUSG00000000216
  
Biological name :Scnn1g
  
Synonyms : Amiloride-sensitive sodium channel subunit gamma / Q9WU39 / Scnn1g
  
Possible biological names infered from orthology : P51170 / sodium channel epithelial 1 gamma subunit
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 121734479
Gene end: 121768475
  
Corresponding Affymetrix probe sets: 10557111 (MoGene1.0st)   1419079_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000221
NCBI entrez gene - 20278     See in Manteia.
MGI - MGI:104695
RefSeq - NM_011326
RefSeq - XM_006507477
RefSeq Peptide - NP_035456
swissprot - Q9WU39
Ensembl - ENSMUSG00000000216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCNN1GENSGALG00000006270Gallus gallus
 P51170ENSG00000166828Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WU38 / Scnn1b / sodium channel, nonvoltage-gated 1 beta / P51168* / sodium channel epithelial 1 beta subunit*ENSMUSG0000003087335
Scnn1a / sodium channel, nonvoltage-gated 1 alpha / P37088* / sodium channel epithelial 1 alpha subunit*ENSMUSG0000003034032
Asic3 / Q6X1Y6 / Acid-sensing ion channel 3 / Q9UHC3* / acid sensing ion channel subunit 3*ENSMUSG0000003827619
Asic1 / Q6NXK8 / Acid-sensing ion channel 1 / P78348* / acid sensing ion channel subunit 1*ENSMUSG0000002301719
Asic2 / Q925H0 / Acid-sensing ion channel 2 / Q16515* / acid sensing ion channel subunit 2*ENSMUSG0000002070418
Asic4 / Q7TNS7 / Acid-sensing ion channel 4 / Q96FT7* / acid sensing ion channel subunit family member 4*ENSMUSG0000003300718
Asic5 / Q9R0Y1 / Acid-sensing ion channel 5 / Q9NY37* / acid sensing ion channel subunit family member 5*ENSMUSG0000002800815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IGI
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0050891 multicellular organismal water homeostasis IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050909 sensory perception of taste IEA
 biological_processGO:0055078 sodium ion homeostasis IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0034706 sodium channel complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IDA
 molecular_functionGO:0015280 ligand-gated sodium channel activity ISO
 molecular_functionGO:0050699 WW domain binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scnn1btm1.1Hum/Scnn1btm1.1Hum
Genetic Background: involves: 129P2/OlaHsd

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011163 increased wet-to-dry lung weight ratio "an increase in the ratio of wet lung weight (measured immediately after lung excision) to oven-dried lung weight relative to control samples; may reflect an inability to expel remaining amniotic fluid out of the lungs during or shortly after birth, or increased fluid accumulation (pulmonary edema) and/or tissue damage after lung injury" [MGI:anna]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011462 increased urine bicarbonate level "an increased amount of bicarbonate in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0014182 decreased respiratory epithelial sodium ion transmembrane transport "decrease in the directed movement of sodium ions from one side of the respiratory epithelial cell membrane to the other" [MGI:csmith]
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0014206 decreased intestinal epithelial sodium ion transmembrane transport 
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Allelic Composition: Igfbp3tm1Jep/Igfbp3tm1Jep,Igfbp4tm1Jep/Igfbp4tm1Jep,Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030873 Q9WU38 / Scnn1b / sodium channel, nonvoltage-gated 1 beta / P51168* / sodium channel epithelial 1 beta subunit*  / complex






 

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