ENSMUSG00000038276


Mus musculus

Features
Gene ID: ENSMUSG00000038276
  
Biological name :Asic3
  
Synonyms : Acid-sensing ion channel 3 / Asic3 / Q6X1Y6
  
Possible biological names infered from orthology : acid sensing ion channel subunit 3 / Q9UHC3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 24413392
Gene end: 24417835
  
Corresponding Affymetrix probe sets: 10520173 (MoGene1.0st)   1439983_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039914
Ensembl peptide - ENSMUSP00000142593
Ensembl peptide - ENSMUSP00000143083
NCBI entrez gene - 171209     See in Manteia.
MGI - MGI:2159339
RefSeq - XM_017320697
RefSeq - NM_001310474
RefSeq - NM_183000
RefSeq - XM_006535637
RefSeq - XM_006535638
RefSeq Peptide - NP_001297403
RefSeq Peptide - NP_892045
swissprot - Q6X1Y6
swissprot - A0A0G2JE16
Ensembl - ENSMUSG00000038276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASIC3ENSG00000213199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asic1 / Q6NXK8 / Acid-sensing ion channel 1 / P78348* / acid sensing ion channel subunit 1*ENSMUSG0000002301749
Asic4 / Q7TNS7 / Acid-sensing ion channel 4 / Q96FT7* / acid sensing ion channel subunit family member 4*ENSMUSG0000003300747
Asic2 / Q925H0 / Acid-sensing ion channel 2 / Q16515* / acid sensing ion channel subunit 2*ENSMUSG0000002070446
Asic5 / Q9R0Y1 / Acid-sensing ion channel 5 / Q9NY37* / acid sensing ion channel subunit family member 5*ENSMUSG0000002800826
Q9WU39 / Scnn1g / Amiloride-sensitive sodium channel subunit gamma / P51170* / sodium channel epithelial 1 gamma subunit*ENSMUSG0000000021623
Scnn1a / sodium channel, nonvoltage-gated 1 alpha / P37088* / sodium channel epithelial 1 alpha subunit*ENSMUSG0000003034023
Q9WU38 / Scnn1b / sodium channel, nonvoltage-gated 1 beta / P51168* / sodium channel epithelial 1 beta subunit*ENSMUSG0000003087322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0009612 response to mechanical stimulus IMP
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0034220 ion transmembrane transport IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042930 enterobactin transport IEA
 biological_processGO:0050907 detection of chemical stimulus involved in sensory perception IMP
 biological_processGO:0050915 sensory perception of sour taste IEA
 biological_processGO:0050961 detection of temperature stimulus involved in sensory perception IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IMP
 biological_processGO:0050968 detection of chemical stimulus involved in sensory perception of pain IMP
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005261 cation channel activity TAS
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0015280 ligand-gated sodium channel activity ISO
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042931 enterobactin transmembrane transporter activity IMP


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008103 amacrine cell degeneration "a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008512 disorganized retinal inner nuclear layer "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008580 photoreceptor inner segment degeneration "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027744 Q6PE84 / Stoml3 / stomatin (Epb7.2)-like 3 / Q8TAV4* / stomatin like 3*  / complex / reaction
 ENSMUSG00000038276 Asic3 / Q6X1Y6 / Acid-sensing ion channel 3 / Q9UHC3* / acid sensing ion channel subunit 3*  / complex






 

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