ENSMUSG00000000544


Mus musculus

Features
Gene ID: ENSMUSG00000000544
  
Biological name :Gpa33
  
Synonyms : glycoprotein A33 (transmembrane) / Gpa33
  
Possible biological names infered from orthology : glycoprotein A33 / Q99795
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.3
Gene start: 166130238
Gene end: 166166510
  
Corresponding Affymetrix probe sets: 10351368 (MoGene1.0st)   1419330_a_at (Mouse Genome 430 2.0 Array)   1454247_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060147
Ensembl peptide - ENSMUSP00000132753
Ensembl peptide - ENSMUSP00000125903
NCBI entrez gene - 59290     See in Manteia.
MGI - MGI:1891703
RefSeq - NM_021610
RefSeq Peptide - NP_067623
swissprot - E9PY15
swissprot - A0A0R4J209
Ensembl - ENSMUSG00000000544
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpa33ENSDARG00000040898Danio rerio
 si:zfos-1011f11.1ENSDARG00000100223Danio rerio
 GPA33ENSGALG00000044138Gallus gallus
 GPA33ENSG00000143167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxadr / P97792 / Coxsackievirus and adenovirus receptor homolog / P78310* / CXADR, Ig-like cell adhesion molecule*ENSMUSG0000002286525
Esam / Q925F2 / Endothelial cell-selective adhesion molecule / Q96AP7* / endothelial cell adhesion molecule*ENSMUSG0000000194624
Igsf11 / P0C673 / Immunoglobulin superfamily member 11 / Q5DX21*ENSMUSG0000002279024
Vsig2 / Q9Z109 / V-set and immunoglobulin domain containing 2 / Q96IQ7*ENSMUSG0000000194323
Vsig8 / Q6P3A4 / V-set and immunoglobulin domain containing 8 / P0DPA2*ENSMUSG0000004959822
Clmp / Q8R373 / CXADR-like membrane protein / Q9H6B4*ENSMUSG0000003202422
Vsig1 / V-set and immunoglobulin domain containing 1 / Q86XK7*ENSMUSG0000003143022
Gm1123ENSMUSG0000004486014


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fsttm1Alsc/Fsttm1Alsc
Genetic Background: Not Specified

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

Allelic Composition: Gpa33tm1Jkhh/Gpa33tm1Jkhh
Genetic Background: involves: 129 * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

 MP:0013298 increased susceptibility to colitis induced morbidity/mortality " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]
Show

Allelic Composition: Gpa33tm1Jkhh/Gpa33tm1Jkhh
Genetic Background: involves: 129 * C57BL/6

 MP:0014201 abnormal intestinal epithelium physiology "any functional anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsMmjax

Allelic Composition: Gpa33tm1Jkhh/Gpa33tm1Jkhh
Genetic Background: involves: 129 * C57BL/6

 MP:0014219 decreased intestinal mucosa thickness 
Show

Allelic Composition: Gpa33tm1Jkhh/Gpa33tm1Jkhh
Genetic Background: involves: 129 * C57BL/6

 MP:0014222 decreased colon goblet cell number 
Show

Allelic Composition: Gpa33tm1Jkhh/Gpa33tm1Jkhh
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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