ENSMUSG00000022865


Mus musculus

Features
Gene ID: ENSMUSG00000022865
  
Biological name :Cxadr
  
Synonyms : Coxsackievirus and adenovirus receptor homolog / Cxadr / P97792
  
Possible biological names infered from orthology : CXADR, Ig-like cell adhesion molecule / P78310
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.1
Gene start: 78301496
Gene end: 78359785
  
Corresponding Affymetrix probe sets: 10436608 (MoGene1.0st)   1427321_s_at (Mouse Genome 430 2.0 Array)   1449949_a_at (Mouse Genome 430 2.0 Array)   1451865_at (Mouse Genome 430 2.0 Array)   1452391_at (Mouse Genome 430 2.0 Array)   1453282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023572
Ensembl peptide - ENSMUSP00000109867
NCBI entrez gene - 13052     See in Manteia.
MGI - MGI:1201679
RefSeq - XM_006522884
RefSeq - NM_001025192
RefSeq - NM_009988
RefSeq - XM_006522883
RefSeq Peptide - NP_001020363
RefSeq Peptide - NP_034118
swissprot - P97792
Ensembl - ENSMUSG00000022865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxadrENSDARG00000043658Danio rerio
 ENSGALG00000015701Gallus gallus
 CXADRENSG00000154639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igsf11 / P0C673 / Immunoglobulin superfamily member 11 / Q5DX21*ENSMUSG0000002279032
Vsig8 / Q6P3A4 / V-set and immunoglobulin domain containing 8 / P0DPA2*ENSMUSG0000004959830
Gm1123ENSMUSG0000004486030
Clmp / Q8R373 / CXADR-like membrane protein / Q9H6B4*ENSMUSG0000003202428
Esam / Q925F2 / Endothelial cell-selective adhesion molecule / Q96AP7* / endothelial cell adhesion molecule*ENSMUSG0000000194626
Vsig2 / Q9Z109 / V-set and immunoglobulin domain containing 2 / Q96IQ7*ENSMUSG0000000194323
Gpa33 / glycoprotein A33 (transmembrane) / Q99795* / glycoprotein A33*ENSMUSG0000000054422
Vsig1 / V-set and immunoglobulin domain containing 1 / Q86XK7*ENSMUSG0000003143021


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008354 germ cell migration IEP
 biological_processGO:0010669 epithelial structure maintenance ISS
 biological_processGO:0030593 neutrophil chemotaxis ISS
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0034109 homotypic cell-cell adhesion ISS
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0046629 gamma-delta T cell activation IDA
 biological_processGO:0048739 cardiac muscle fiber development IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IC
 biological_processGO:0070633 transepithelial transport ISO
 biological_processGO:0086067 AV node cell to bundle of His cell communication IMP
 biological_processGO:0086072 AV node cell-bundle of His cell adhesion involved in cell communication IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:0098904 regulation of AV node cell action potential IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005912 adherens junction ISO
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane ISO
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0031594 neuromuscular junction ISO
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050839 cell adhesion molecule binding ISS
 molecular_functionGO:0071253 connexin binding IPI
 molecular_functionGO:0086082 cell adhesive protein binding involved in AV node cell-bundle of His cell communication IC


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Pygo2tm1.1Ssp/Pygo2tm1.2Ssp,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0004114 abnormal atrioventricular node morphology "structural anomaly in the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ay/a,Ednrbs/Ednrbs
Genetic Background: Not Specified

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0006141 abnormal atrioventricular node conduction "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou3f4Slf/Pou3f4Slf
Genetic Background: C3H101H-Pou3f4Slf

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0010510 absent P wave "absence of the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cxadrtm1Know/Cxadrtm1Know,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * Black Swiss * FVB/N

Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cxadrtm1Dvst/Cxadrtm1Dvst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cxadrtm1.1Mds/Cxadrtm1.1Mds
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Cxadrtm1Mds/Cxadrtm1.1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cxadrtm1Mds/Cxadrtm1Mds,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cxadrtm1Mgot/Cxadrtm1Mgot,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

Allelic Composition: Cxadrtm2Know/Cxadrtm2Know
Genetic Background: involves: 129 * Black Swiss

 MP:0013221 pancreatic acinar-to-ductal metaplasia "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna]
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Allelic Composition: Cxadrtm1.1Ics/Cxadrtm1.1Ics,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
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Allelic Composition: Cxadrtm1Dvst/Cxadrtm1Dvst
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048534 Jaml / Q80UL9 / Junctional adhesion molecule-like / Q86YT9* / junction adhesion molecule like*  / complex / reaction






 

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