ENSG00000154639


Homo sapiens

Features
Gene ID: ENSG00000154639
  
Biological name :CXADR
  
Synonyms : CXADR / CXADR, Ig-like cell adhesion molecule / P78310
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q21.1
Gene start: 17512382
Gene end: 17593579
  
Corresponding Affymetrix probe sets: 1555716_a_at (Human Genome U133 Plus 2.0 Array)   203917_at (Human Genome U133 Plus 2.0 Array)   226374_at (Human Genome U133 Plus 2.0 Array)   239155_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383029
Ensembl peptide - ENSP00000284878
Ensembl peptide - ENSP00000348620
Ensembl peptide - ENSP00000383030
Ensembl peptide - ENSP00000383033
NCBI entrez gene - 1525     See in Manteia.
OMIM - 602621
RefSeq - XM_011529479
RefSeq - NM_001207063
RefSeq - NM_001207064
RefSeq - NM_001207065
RefSeq - NM_001207066
RefSeq - NM_001338
RefSeq - XM_011529476
RefSeq - XM_011529477
RefSeq - XM_011529478
RefSeq Peptide - NP_001329
RefSeq Peptide - NP_001193992
RefSeq Peptide - NP_001193993
RefSeq Peptide - NP_001193994
RefSeq Peptide - NP_001193995
swissprot - P78310
Ensembl - ENSG00000154639
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxadrENSDARG00000043658Danio rerio
 ENSGALG00000015701Gallus gallus
 CxadrENSMUSG00000022865Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGSF11 / Q5DX21 / immunoglobulin superfamily member 11ENSG0000014484733
CLMP / Q9H6B4 / CXADR like membrane proteinENSG0000016625031
VSIG8 / P0DPA2 / V-set and immunoglobulin domain containing 8ENSG0000024328430
ESAM / Q96AP7 / endothelial cell adhesion moleculeENSG0000014956425
GPA33 / Q99795 / glycoprotein A33ENSG0000014316724
VSIG2 / Q96IQ7 / V-set and immunoglobulin domain containing 2ENSG0000001910223
VSIG1 / Q86XK7 / V-set and immunoglobulin domain containing 1ENSG0000010184222


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008354 germ cell migration ISS
 biological_processGO:0010669 epithelial structure maintenance IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0045216 cell-cell junction organization ISS
 biological_processGO:0046629 gamma-delta T cell activation ISS
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048739 cardiac muscle fiber development ISS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0070633 transepithelial transport IMP
 biological_processGO:0086067 AV node cell to bundle of His cell communication ISS
 biological_processGO:0086072 AV node cell-bundle of His cell adhesion involved in cell communication ISS
 biological_processGO:0098904 regulation of AV node cell action potential ISS
 cellular_componentGO:0001669 acrosomal vesicle ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0044297 cell body ISS
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0071253 connexin binding ISS
 molecular_functionGO:0086082 cell adhesive protein binding involved in AV node cell-bundle of His cell communication IC


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160593 JAML / Q86YT9 / junction adhesion molecule like  / complex / reaction






 

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