ENSMUSG00000000826


Mus musculus

Features
Gene ID: ENSMUSG00000000826
  
Biological name :Dnajc5
  
Synonyms : Dnajc5 / DnaJ homolog subfamily C member 5 / P60904
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member C5 / Q9H3Z4
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 181520485
Gene end: 181555133
  
Corresponding Affymetrix probe sets: 10479639 (MoGene1.0st)   1436179_a_at (Mouse Genome 430 2.0 Array)   1436180_at (Mouse Genome 430 2.0 Array)   1448850_a_at (Mouse Genome 430 2.0 Array)   1448851_a_at (Mouse Genome 430 2.0 Array)   1460498_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116120
Ensembl peptide - ENSMUSP00000072175
Ensembl peptide - ENSMUSP00000104424
Ensembl peptide - ENSMUSP00000104425
Ensembl peptide - ENSMUSP00000112066
NCBI entrez gene - 13002     See in Manteia.
MGI - MGI:892995
RefSeq - NM_016775
RefSeq - XM_011239923
RefSeq - NM_001271584
RefSeq - NM_001271585
RefSeq Peptide - NP_001258513
RefSeq Peptide - NP_001258514
RefSeq Peptide - NP_058055
swissprot - A2AUE1
swissprot - G5E8T0
swissprot - P60904
Ensembl - ENSMUSG00000000826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajc5aaENSDARG00000042948Danio rerio
 dnajc5abENSDARG00000004836Danio rerio
 DNAJC5ENSGALG00000035378Gallus gallus
 DNAJC5ENSG00000101152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CQ94 / Dnajc5b / DnaJ homolog subfamily C member 5B / Q9UF47* / DnaJ heat shock protein family (Hsp40) member C5 beta*ENSMUSG0000002760667
Dnajc5g / dnaJ homolog subfamily C member 5G isoform 2 / Q8N7S2* / DnaJ heat shock protein family (Hsp40) member C5 gamma*ENSMUSG0000005385643
Q149L6 / Dnajb14 / DnaJ homolog subfamily B member 14 / Q8TBM8* / DnaJ heat shock protein family (Hsp40) member B14*ENSMUSG0000007421229
Q9QYI4 / Dnajb12 / DnaJ homolog subfamily B member 12 / Q9NXW2* / DnaJ heat shock protein family (Hsp40) member B12*ENSMUSG0000002010928
Q9CZJ9 / Dnajc18 / DnaJ homolog subfamily C member 18 / Q9H819* / DnaJ heat shock protein family (Hsp40) member C18*ENSMUSG0000002435026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR018253  DnaJ domain, conserved site
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043008 ATP-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA)1Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA)1Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006326 conductive hearing impairment " reduction in the ability to hear due to lesions in the external auditory canal or middle ear" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006336 abnormal otoacoustic response "anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-Snca)M1mSud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA)1Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Gnastm1Kel/Gnas+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Tg(THY1-SNCA*A30P)TS2Sud/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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