Manteia

ENSMUSG00000000861

Mus musculus

Features

Gene ID:	ENSMUSG00000000861

Biological name :	Bcl11a

Synonyms :	B-cell lymphoma/leukemia 11A / Bcl11a / Q9QYE3

Possible biological names infered from orthology :	B cell CLL/lymphoma 11A / Q9H165

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A3.2
Gene start:	24078056
Gene end:	24174123

Corresponding Affymetrix probe sets:	10374727 (MoGene1.0st) 1419406_a_at (Mouse Genome 430 2.0 Array) 1426552_a_at (Mouse Genome 430 2.0 Array) 1447334_at (Mouse Genome 430 2.0 Array) 1447335_x_at (Mouse Genome 430 2.0 Array) 1453814_at (Mouse Genome 430 2.0 Array) 1456632_at (Mouse Genome 430 2.0 Array) 1457072_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000000881 Ensembl peptide - ENSMUSP00000105140 Ensembl peptide - ENSMUSP00000105142 Ensembl peptide - ENSMUSP00000112948 NCBI entrez gene - 14025 See in Manteia. MGI - MGI:106190 RefSeq - XM_011243660 RefSeq - NM_001159289 RefSeq - NM_001159290 RefSeq - NM_001242934 RefSeq - NM_016707 RefSeq - XM_006514504 RefSeq - XM_006514505 RefSeq - XM_006514506 RefSeq - XM_006514507 RefSeq - XM_011243659 RefSeq Peptide - NP_001152761 RefSeq Peptide - NP_001152762 RefSeq Peptide - NP_001229863 RefSeq Peptide - NP_057916 swissprot - Q5STS9 swissprot - Q9QYE3 Ensembl - ENSMUSG00000000861

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
bcl11aa	ENSDARG00000061352	Danio rerio
bcl11ab	ENSDARG00000063153	Danio rerio
BCL11A	ENSGALG00000034048	Gallus gallus
BCL11A	ENSG00000119866	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rit1 / Q99PV8 / B cell leukemia/lymphoma 11B / BCL11B* / Q9C0K0* / B cell CLL/lymphoma 11B*	ENSMUSG00000048251	60
E9Q6W4 / Zfp296 / zinc finger protein 296 / Q8WUU4* / ZNF296*	ENSMUSG00000011267	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IBA
biological_process	GO:0007165	signal transduction	IBA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010629	negative regulation of gene expression	IMP
biological_process	GO:0010976	positive regulation of neuron projection development	ISO
biological_process	GO:0010977	negative regulation of neuron projection development	ISO
biological_process	GO:0016925	protein sumoylation	IMP
biological_process	GO:0022008	neurogenesis	IBA
biological_process	GO:0030183	B cell differentiation	IMP
biological_process	GO:0030217	T cell differentiation	IMP
biological_process	GO:0048671	negative regulation of collateral sprouting	ISO
biological_process	GO:0048672	positive regulation of collateral sprouting	ISO
biological_process	GO:0050773	regulation of dendrite development	ISO
biological_process	GO:1903860	negative regulation of dendrite extension	IEA
biological_process	GO:1904800	negative regulation of neuron remodeling	IEA
biological_process	GO:1905232	cellular response to L-glutamate	IEA
biological_process	GO:2000171	negative regulation of dendrite development	IEA
biological_process	GO:2000173	negative regulation of branching morphogenesis of a nerve	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0014069	postsynaptic density	IEA
cellular_component	GO:0016604	nuclear body	IDA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IBA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003714	transcription corepressor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IBA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IBA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Dnmt1^tm2Jae/Dnmt1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Kalrn^tm1Ppen/Kalrn⁺ Genetic Background: Not Specified Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000726	absent lymphocyte	"lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Itga2^tm1.1Tkun/Itga2^tm1.1Tkun,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Dnmt1^tm2Jae/Dnmt1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a⁺,Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Genetic Background: involves: 129 * BALB/cJ
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺ Genetic Background: involves: 129S1/Sv
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a⁺,Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Genetic Background: involves: 129 * BALB/cJ
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Dnmt1^tm2Jae/Dnmt1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Kdm1a^tm1.1Sho/Kdm1a⁺,Epor^{tm1(EGFP/cre)Uk}/Epor⁺ Genetic Background: involves: 129 * BALB/cJ
MP:0002910	abnormal excitatory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0003790	absent CD4+8- cells	"lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Trp53^tm1Brn/Trp53^tm1Brn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺ Genetic Background: involves: 129S1/Sv
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0005563	abnormal hemoglobin content	"deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kalrn^tm1Ppen/Kalrn⁺ Genetic Background: Not Specified
MP:0006282	abnormal posterior horn morphology	"any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0008071	absent B cells	"absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008115	abnormal dendritic cell differentiation	"atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008124	decreased plasmacytoid dendritic cell number	"reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008127	decreased dendritic cell number	"reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0008249	abnormal common lymphocyte progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺ Genetic Background: involves: 129S1/Sv
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0008574	decreased circulating interferon-alpha level	"reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]	Show Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008760	abnormal immunoglobulin heavy chain V(D)J recombination	"any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0010132	decreased DN2 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺ Genetic Background: involves: 129S1/Sv
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli,Trp53^tm1Brn/Trp53^tm1Brn,Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Mos^tm1Sia/Mos^tm1Sia Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri Genetic Background: involves: BALB/cJ
MP:0011285	increased circulating erythropoietin level	"greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Klf1^tm1Nimr/Klf1⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Bcl11a^tm1Mbu/Bcl11a^tm1Mbu,Epor^{tm1(EGFP/cre)Uk}/Epor⁺,Tg(HBB)8.1Gvs/0 Genetic Background: involves: 129 * BALB/cJ * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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