ENSMUSG00000048251


Mus musculus

Features
Gene ID: ENSMUSG00000048251
  
Biological name :Rit1
  
Synonyms : B cell leukemia/lymphoma 11B / Q99PV8 / Rit1
  
Possible biological names infered from orthology : B cell CLL/lymphoma 11B / BCL11B / Q9C0K0
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 107910403
Gene end: 108003602
  
Corresponding Affymetrix probe sets: 10402554 (MoGene1.0st)   1435227_at (Mouse Genome 430 2.0 Array)   1438784_at (Mouse Genome 430 2.0 Array)   1450339_a_at (Mouse Genome 430 2.0 Array)   1452966_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068258
Ensembl peptide - ENSMUSP00000105513
Ensembl peptide - ENSMUSP00000105517
NCBI entrez gene - 58208     See in Manteia.
MGI - MGI:1929913
RefSeq - XM_017315145
RefSeq - NM_001079883
RefSeq - NM_001286343
RefSeq - NM_021399
RefSeq - XM_006516111
RefSeq - XM_006516114
RefSeq - XM_011244153
RefSeq - XM_017315143
RefSeq - XM_017315144
RefSeq Peptide - NP_001073352
RefSeq Peptide - NP_001273272
RefSeq Peptide - NP_067374
swissprot - Q99PV8
swissprot - A0A0R4J1E1
Ensembl - ENSMUSG00000048251
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 im:7142702ENSDARG00000116556Danio rerio
 BCL11BENSGALG00000031862Gallus gallus
 BCL11BENSG00000127152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl11a / Q9QYE3 / B-cell lymphoma/leukemia 11A / Q9H165* / B cell CLL/lymphoma 11A*ENSMUSG0000000086156
E9Q6W4 / Zfp296 / zinc finger protein 296 / Q8WUU4* / ZNF296*ENSMUSG0000001126717


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003334 keratinocyte development IMP
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010837 regulation of keratinocyte proliferation IMP
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0021773 striatal medium spiny neuron differentiation IMP
 biological_processGO:0021902 commitment of neuronal cell to specific neuron type in forebrain IGI
 biological_processGO:0021953 central nervous system neuron differentiation IGI
 biological_processGO:0031077 post-embryonic camera-type eye development IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033153 T cell receptor V(D)J recombination IMP
 biological_processGO:0035701 hematopoietic stem cell migration ISS
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043368 positive T cell selection IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046632 alpha-beta T cell differentiation IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0071678 olfactory bulb axon guidance IMP
 biological_processGO:0097535 lymphoid lineage cell migration into thymus ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: UmodUrehd1/UmodUrehd1
Genetic Background: involves: C3HeB/FeJ

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plgtm1Dco/Plgtm1Dco,Tg(Alb-PLG)1Dgi/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plgtm1Dco/Plgtm1Dco,Tg(Alb-PLG)1Dgi/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Plgtm1Dco/Plgtm1Dco,Tg(Alb-PLG)1Dgi/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tcratm1Mom/Tcratm1Mom,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Plgtm1Dco/Plgtm1Dco,Tg(Alb-PLG)1Dgi/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tcratm1Mom/Tcratm1Mom,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tcratm1Mom/Tcratm1Mom,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bcl11btm1Avram/Bcl11btm1Avram,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010864 abnormal enamel knot morphology "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0012085 midface hypoplasia "underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0013741 absent thymus corticomedullary boundary " complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:Anna, PMID:17067941]
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Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0030420 short basicranium "decreased length of the anterior and/or posterior portions of the skull base" [MGI:anna]
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Allelic Composition: Bcl11bm1Jpk/Bcl11btm1Jpk
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0030453 abnormal odontoblast morphology "any structural anomaly of the skeletogenic cell on the outer surface of the dental pulp that secretes dentin matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell" [CL:0000060, GO:0071895]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0030471 abnormal ameloblast differentiation "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a functional ameloblast, a tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ of a developing tooth involved with the formation of enamel matrix" [GO:0036305, PMID:19090561]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0030518 abnormal outer dental epithelium morphology "any structural anomaly of the layer of cuboidal cells located on the periphery of the enamel organ in a developing tooth; this layer is first seen during the bell stage" [https://en.wikipedia.org/wiki/Outer_enamel_epithelium]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0030522 abnormal stellate reticulum morphology "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

 MP:0030526 abnormal enamel cord morphology "any structural anomaly of the transient structure of the dental (enamel) organ present at the early cap stage of molar tooth development; the enamel cord is a strand of epithelial cells that runs from (links) the enamel knot to the outer dental epithelial cells, dividing the dental organ into two parts" [https://en.wikipedia.org/wiki/Enamel_cord, ISBN:978-0-12-597951-1]
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Allelic Composition: Bcl11btm1.2Leid/Bcl11btm1.2Leid
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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