ENSMUSG00000000934


Mus musculus

Features
Gene ID: ENSMUSG00000000934
  
Biological name :Top1mt
  
Synonyms : Mus musculus DNA topoisomerase 1, mitochondrial (Top1mt), transcript variant 2, mRNA. / Q8R4U6 / Top1mt
  
Possible biological names infered from orthology : DNA topoisomerase I mitochondrial / Q969P6
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 75657035
Gene end: 75678800
  
Corresponding Affymetrix probe sets: 10429607 (MoGene1.0st)   1460370_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000958
NCBI entrez gene - 72960     See in Manteia.
MGI - MGI:1920210
RefSeq - XM_006521466
RefSeq - NM_001355589
RefSeq - NM_028404
RefSeq Peptide - NP_082680
RefSeq Peptide - NP_001342518
swissprot - Q8R4U6
Ensembl - ENSMUSG00000000934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1mtENSDARG00000104809Danio rerio
 TOP1MTENSGALG00000029572Gallus gallus
 Q969P6ENSG00000184428Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Top1 / Q04750 / DNA topoisomerase 1 / P11387* / DNA topoisomerase I*ENSMUSG0000007054463


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR025834  Topoisomerase I C-terminal domain
 IPR036202  DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0006265 DNA topological change IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IBA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003925 abnormal cellular glucose import "anomaly in the ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011628 increased mitochondria number "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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