ENSG00000184428


Homo sapiens

Features
Gene ID: ENSG00000184428
  
Biological name :TOP1MT
  
Synonyms : DNA topoisomerase I mitochondrial / Q969P6 / TOP1MT
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 143304384
Gene end: 143359979
  
Corresponding Affymetrix probe sets: 1560757_at (Human Genome U133 Plus 2.0 Array)   225802_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428451
Ensembl peptide - ENSP00000430679
Ensembl peptide - ENSP00000430635
Ensembl peptide - ENSP00000430209
Ensembl peptide - ENSP00000430139
Ensembl peptide - ENSP00000429181
Ensembl peptide - ENSP00000429177
Ensembl peptide - ENSP00000429169
Ensembl peptide - ENSP00000428931
Ensembl peptide - ENSP00000428727
Ensembl peptide - ENSP00000428723
Ensembl peptide - ENSP00000328835
Ensembl peptide - ENSP00000427925
Ensembl peptide - ENSP00000427998
Ensembl peptide - ENSP00000428369
NCBI entrez gene - 116447     See in Manteia.
OMIM - 606387
RefSeq - NM_001258447
RefSeq - NM_052963
RefSeq - NM_001258446
RefSeq - XM_005250781
RefSeq Peptide - NP_443195
RefSeq Peptide - NP_001245375
RefSeq Peptide - NP_001245376
swissprot - E5KMK7
swissprot - E5RJ95
swissprot - H0YBR3
swissprot - H0YC03
swissprot - Q969P6
swissprot - H0YAR3
swissprot - E5RJ33
swissprot - E5RIC7
swissprot - E5RGR4
swissprot - E5RGR2
swissprot - E5RGE7
swissprot - E5RFS0
swissprot - E5RFE3
Ensembl - ENSG00000184428
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1mtENSDARG00000104809Danio rerio
 TOP1MTENSGALG00000029572Gallus gallus
 Q8R4U6ENSMUSG00000000934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP1 / P11387 / DNA topoisomerase IENSG0000019890066


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR018521  DNA topoisomerase I, active site
 IPR025834  Topoisomerase I C-terminal domain
 IPR036202  DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0006265 DNA topological change IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0042645 mitochondrial nucleoid IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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