ENSG00000198900


Homo sapiens

Features
Gene ID: ENSG00000198900
  
Biological name :TOP1
  
Synonyms : DNA topoisomerase I / P11387 / TOP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q12
Gene start: 41028818
Gene end: 41124487
  
Corresponding Affymetrix probe sets: 208900_s_at (Human Genome U133 Plus 2.0 Array)   208901_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354522
NCBI entrez gene - 7150     See in Manteia.
OMIM - 126420
RefSeq - NM_003286
RefSeq Peptide - NP_003277
swissprot - P11387
Ensembl - ENSG00000198900
  
Related genetic diseases (OMIM): 126420 - DNA topoisomerase I, camptothecin-resistant
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1ENSDARG00000086775Danio rerio
 top1lENSDARG00000070545Danio rerio
 TOP1ENSGALG00000003681Gallus gallus
 Top1ENSMUSG00000070544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q969P6 / TOP1MT / DNA topoisomerase I mitochondrialENSG0000018442852


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR018521  DNA topoisomerase I, active site
 IPR025834  Topoisomerase I C-terminal domain
 IPR036202  DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006265 DNA topological change IMP
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0012501 programmed cell death NAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation NAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IMP
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0040016 embryonic cleavage IEA
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IMP
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IMP
 cellular_componentGO:0031298 replication fork protection complex IBA
 cellular_componentGO:0032993 protein-DNA complex IMP
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IMP
 molecular_functionGO:0003697 single-stranded DNA binding IMP
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0097100 supercoiled DNA binding IMP


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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