ENSGALG00000003681


Gallus gallus

Features
Gene ID: ENSGALG00000003681
  
Biological name :TOP1
  
Synonyms : DNA topoisomerase 1 / TOP1
  
Possible biological names infered from orthology : DNA topoisomerase I / P11387 / Q04750
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 4865269
Gene end: 5043775
  
Corresponding Affymetrix probe sets: Gga.3987.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005822
Ensembl peptide - ENSGALP00000043331
NCBI entrez gene - 396004     See in Manteia.
RefSeq - NM_205110
RefSeq Peptide - NP_990441
swissprot - F1NPT1
swissprot - R4GM79
Ensembl - ENSGALG00000003681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top1ENSDARG00000086775Danio rerio
 top1lENSDARG00000070545Danio rerio
 TOP1ENSG00000198900Homo sapiens
 Top1ENSMUSG00000070544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP1MT / DNA topoisomerase I, mitochondrial / Q8R4U6* / Q969P6* / Mus musculus DNA topoisomerase 1, mitochondrial (Top1mt), transcript variant 2, mRNA.*ENSGALG0000002957248


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR018521  DNA topoisomerase I, active site
 IPR025834  Topoisomerase I C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006265 DNA topological change IBA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0040016 embryonic cleavage IEA
 biological_processGO:0042493 response to drug IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IEA
 cellular_componentGO:0031298 replication fork protection complex IBA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IBA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0097100 supercoiled DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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