ENSDARG00000070545


Danio rerio

Features
Gene ID: ENSDARG00000070545
  
Biological name :top1l
  
Synonyms : DNA topoisomerase I, like / top1l
  
Possible biological names infered from orthology : DNA topoisomerase 1 / DNA topoisomerase I / P11387 / Q04750 / TOP1
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 25296366
Gene end: 25311677
  
Corresponding Affymetrix probe sets: Dr.24558.2.S1_at (Zebrafish Array)   Dr.25496.1.A1_at (Zebrafish Array)   Dr.25496.2.S1_at (Zebrafish Array)   Dr.5335.2.S1_at (Zebrafish Array)   DrAffx.2.70.A1_at (Zebrafish Array)   DrAffx.2.70.A1_s_at (Zebrafish Array)   NM_001044324_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139289
Ensembl peptide - ENSDARP00000065948
NCBI entrez gene - 553496     See in Manteia.
RefSeq - NM_001044324
RefSeq Peptide - NP_001037789
swissprot - A0A0R4IST9
swissprot - Q1ED17
ZFIN ID - ZDB-GENE-060616-217
Ensembl - ENSDARG00000070545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOP1ENSGALG00000003681Gallus gallus
 TOP1ENSG00000198900Homo sapiens
 Top1ENSMUSG00000070544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
top1 / DNA topoisomerase I / P11387* / Q04750* / DNA topoisomerase 1 *ENSDARG0000008677563
zgc:173742ENSDARG0000000452946
top1mt / DNA topoisomerase I mitochondrial / Q969P6*ENSDARG0000010480945


Protein motifs (from Interpro)
Interpro ID Name
 IPR001631  DNA topoisomerase I
 IPR008336  DNA topoisomerase I, DNA binding, eukaryotic-type
 IPR011010  DNA breaking-rejoining enzyme, catalytic core
 IPR013030  DNA topoisomerase I, DNA binding, N-terminal domain 2
 IPR013034  DNA topoisomerase I, DNA binding, N-terminal domain 1
 IPR013499  DNA topoisomerase I, eukaryotic-type
 IPR013500  DNA topoisomerase I, catalytic core, eukaryotic-type
 IPR014711  DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR018521  DNA topoisomerase I, active site
 IPR025834  Topoisomerase I C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0007059 chromosome segregation IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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