ENSMUSG00000001098


Mus musculus

Features
Gene ID: ENSMUSG00000001098
  
Biological name :Kctd10
  
Synonyms : Kctd10 / potassium channel tetramerisation domain containing 10 / Q922M3
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114363567
Gene end: 114380508
  
Corresponding Affymetrix probe sets: 10532819 (MoGene1.0st)   1423694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001125
Ensembl peptide - ENSMUSP00000099641
Ensembl peptide - ENSMUSP00000138564
NCBI entrez gene - 330171     See in Manteia.
MGI - MGI:2141207
RefSeq - NM_001159941
RefSeq - NM_026145
RefSeq Peptide - NP_001153413
RefSeq Peptide - NP_080421
swissprot - S4R2A3
swissprot - Q922M3
swissprot - F8WGQ9
Ensembl - ENSMUSG00000001098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70479 / Tnfaip1 / tumor necrosis factor, alpha-induced protein 1 (endothelial) / Q13829* / TNF alpha induced protein 1*ENSMUSG0000001761569
Kctd13 / Q8BGV7 / potassium channel tetramerisation domain containing 13 / Q8WZ19* / potassium channel tetramerization domain containing 13*ENSMUSG0000003068567
Kctd14 / Q9BQ13* / potassium channel tetramerization domain containing 14*ENSMUSG0000005172718
Kctd7 / Q8BJK1 / BTB/POZ domain-containing protein KCTD7 / Q96MP8* / potassium channel tetramerization domain containing 7*ENSMUSG0000003411018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR011333  SKP1/BTB/POZ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISS
 cellular_componentGO:0036038 MKS complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0003230 abnormal umbilical artery "malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

 MP:0012730 abnormal internal carotid artery morphology "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]
Show

Allelic Composition: Tbrg1tm1a(KOMP)Wtsi/Tbrg1+
Genetic Background: C57BL/6N-Tbrg1tm1a(KOMP)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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