ENSMUSG00000017615


Mus musculus

Features
Gene ID: ENSMUSG00000017615
  
Biological name :Tnfaip1
  
Synonyms : O70479 / Tnfaip1 / tumor necrosis factor, alpha-induced protein 1 (endothelial)
  
Possible biological names infered from orthology : Q13829 / TNF alpha induced protein 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78522850
Gene end: 78536332
  
Corresponding Affymetrix probe sets: 10388869 (MoGene1.0st)   1417865_at (Mouse Genome 430 2.0 Array)   1417866_at (Mouse Genome 430 2.0 Array)   1448863_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017759
Ensembl peptide - ENSMUSP00000103912
NCBI entrez gene - 21927     See in Manteia.
MGI - MGI:104961
RefSeq - NM_001159392
RefSeq - NM_009395
RefSeq Peptide - NP_001152864
RefSeq Peptide - NP_033421
swissprot - O70479
Ensembl - ENSMUSG00000017615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaip1ENSDARG00000041565Danio rerio
 TNFAIP1ENSGALG00000005715Gallus gallus
 Q13829ENSG00000109079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kctd10 / Q922M3 / potassium channel tetramerisation domain containing 10ENSMUSG0000000109869
Kctd13 / Q8BGV7 / potassium channel tetramerisation domain containing 13 / Q8WZ19* / potassium channel tetramerization domain containing 13*ENSMUSG0000003068563
Kctd7 / Q8BJK1 / BTB/POZ domain-containing protein KCTD7 / Q96MP8* / potassium channel tetramerization domain containing 7*ENSMUSG0000003411018
Kctd14 / Q9BQ13* / potassium channel tetramerization domain containing 14*ENSMUSG0000005172716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR011333  SKP1/BTB/POZ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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