ENSMUSG00000001157


Mus musculus

Features
Gene ID: ENSMUSG00000001157
  
Biological name :Gmcl1
  
Synonyms : germ cell-less, spermatogenesis associated 1 / Gmcl1 / Q920G9
  
Possible biological names infered from orthology : Q96IK5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 86691768
Gene end: 86733383
  
Corresponding Affymetrix probe sets: 10545940 (MoGene1.0st)   1417113_at (Mouse Genome 430 2.0 Array)   1417114_at (Mouse Genome 430 2.0 Array)   1432598_at (Mouse Genome 430 2.0 Array)   1438887_a_at (Mouse Genome 430 2.0 Array)   1438888_at (Mouse Genome 430 2.0 Array)   1454292_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001185
Ensembl peptide - ENSMUSP00000109309
NCBI entrez gene - 23885     See in Manteia.
MGI - MGI:1345156
RefSeq - XM_006506056
RefSeq - NM_011818
RefSeq Peptide - NP_035948
swissprot - Q3V0Z2
swissprot - Q920G9
Ensembl - ENSMUSG00000001157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gmcl1ENSDARG00000020948Danio rerio
 GMCL1ENSG00000087338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btbd35f4 / BTB domain containing 35, family member 4ENSMUSG0000007821344
Btbd35f19 / BTB domain containing 35, family member 19ENSMUSG0000009435244
Btbd35f26 / BTB domain containing 35, family member 26ENSMUSG0000009522944
Btbd35f17 / BTB domain containing 35, family member 17ENSMUSG0000009427344
Btbd35f29 / BTB domain containing 35, family member 29ENSMUSG0000009439144
Btbd35f22 / BTB domain containing 35, family member 22ENSMUSG0000009385744
Btbd35f1 / BTB domain containing 35, family member 1ENSMUSG0000009430944
Btbd35f16 / BTB domain containing 35, family member 16ENSMUSG0000010138144
Btbd35f10 / BTB domain containing 35, family member 10ENSMUSG0000009571644
Btbd35f7 / BTB domain containing 35, family member 7ENSMUSG0000009581444
Btbd35f11 / BTB domain containing 35, family member 11ENSMUSG0000009455844
Btbd35f15 / BTB domain containing 35, family member 15ENSMUSG0000010129444
Btbd35f21 / BTB domain containing 35, family member 21ENSMUSG0000009971144
Btbd35f3 / BTB domain containing 35, family member 3ENSMUSG0000007821844
Btbd35f28 / BTB domain containing 35, family member 28ENSMUSG0000009430744
Btbd35f20 / BTB domain containing 35, family member 20ENSMUSG0000009459644
Btbd35f24 / BTB domain containing 35, family member 24ENSMUSG0000009642644
Btbd35f2 / BTB domain containing 35, family member 2ENSMUSG0000009619444
Btbd35f6 / BTB domain containing 35, family member 6ENSMUSG0000009691544
Q99N64 / Btbd35f5 / BTB domain containing 35, family member 5ENSMUSG0000009472744


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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