ENSMUSG00000001348


Mus musculus

Features
Gene ID: ENSMUSG00000001348
  
Biological name :Acp5
  
Synonyms : Acp5 / Q05117 / Tartrate-resistant acid phosphatase type 5
  
Possible biological names infered from orthology : acid phosphatase 5, tartrate resistant / P13686
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 22126727
Gene end: 22135711
  
Corresponding Affymetrix probe sets: 10591739 (MoGene1.0st)   1431609_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150903
Ensembl peptide - ENSMUSP00000110970
Ensembl peptide - ENSMUSP00000127128
Ensembl peptide - ENSMUSP00000065425
Ensembl peptide - ENSMUSP00000149597
NCBI entrez gene - 11433     See in Manteia.
MGI - MGI:87883
RefSeq - XM_011242384
RefSeq - NM_001102404
RefSeq - NM_001102405
RefSeq - NM_007388
RefSeq - XM_006509944
RefSeq - XM_006509945
RefSeq - XM_006509946
RefSeq Peptide - NP_001095874
RefSeq Peptide - NP_001095875
RefSeq Peptide - NP_031414
swissprot - Q05117
Ensembl - ENSMUSG00000001348
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acp5aENSDARG00000019763Danio rerio
 ACP5ENSG00000102575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR024927  Acid phosphatase, type 5
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032929 negative regulation of superoxide anion generation IMP
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0060349 bone morphogenesis IMP
 cellular_componentGO:0005764 lysosome IMP
 molecular_functionGO:0003993 acid phosphatase activity IMP
 molecular_functionGO:0008198 ferrous iron binding ISS
 molecular_functionGO:0008199 ferric iron binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin B2 (riboflavin) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0000132 thickened epiphysis "wider than normal part of the long bones that initially develops from a distinct ossification center than the shaft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0006394 abnormal vertebral epiphyseal plate morphology "any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001348 Acp5 / Q05117 / Tartrate-resistant acid phosphatase type 5 / P13686* / acid phosphatase 5, tartrate resistant*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr