ENSMUSG00000001855


Mus musculus

Features
Gene ID: ENSMUSG00000001855
  
Biological name :Nup214
  
Synonyms : Nuclear pore complex protein Nup214 / Nup214 / Q80U93
  
Possible biological names infered from orthology : nucleoporin 214 / P35658
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31974436
Gene end: 32053975
  
Corresponding Affymetrix probe sets: 10471256 (MoGene1.0st)   1434351_at (Mouse Genome 430 2.0 Array)   1456503_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066492
Ensembl peptide - ENSMUSP00000142255
Ensembl peptide - ENSMUSP00000141436
Ensembl peptide - ENSMUSP00000115665
NCBI entrez gene - 227720     See in Manteia.
MGI - MGI:1095411
RefSeq - XM_006497945
RefSeq - XM_017317375
RefSeq - XM_006497946
RefSeq - NM_172268
RefSeq Peptide - NP_758472
swissprot - Q80U93
swissprot - A2ATN3
swissprot - A0A0A6YW83
swissprot - A0A0A6YY32
Ensembl - ENSMUSG00000001855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup214ENSDARG00000016212Danio rerio
 NUP214ENSGALG00000041111Gallus gallus
 NUP214ENSG00000126883Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR026054  Nuclear pore complex protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044613 nuclear pore central transport channel IBA
 cellular_componentGO:0044615 nuclear pore nuclear basket IBA
 cellular_componentGO:1990876 cytoplasmic side of nuclear pore IEA
 molecular_functionGO:0005049 nuclear export signal receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0017056 structural constituent of nuclear pore IBA


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
HuR (ELAVL1) binds and stabilizes mRNA
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004963 abnormal blastocoele morphology "any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem
Genetic Background: B6.Cg-L1camtm1.1Vlem

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem
Genetic Background: B6.Cg-L1camtm1.1Vlem

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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