| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0000069 | kyphoscoliosis | "kyphosis combined with scoliosis" [MGI:CML, J:66943] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0000141 | abnormal vertebral body morphology | "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0000162 | lordosis | "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000422 | delayed hair appearance | "late onset of the first appearance of the fur" [J:17792] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000873 | thin external granule cell layer | "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000875 | abnormal cerebellar Purkinje cell layer | "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000885 | ectopic Purkinje cell | "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000888 | absent cerebellar granule layer | "missing innermost cortical layer of the cerebellum" [J:46854] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000889 | abnormal cerebellar molecular layer | "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000952 | abnormal CNS glia | "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001231 | abnormal basal cell layer morphology | "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001243 | abnormal dermal layer morphology | "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001255 | decreased body height | "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0003795 | abnormal bone structure | |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0004604 | abnormal vertebral pedicle morphology | "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0005060 | accumulation of giant lysosomes in kidney/renal tubule cells | "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5590] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
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| MP:0008572 | abnormal Purkinje cell dendrite morphology | "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0009351 | thin hair shaft | "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0010932 | increased trabecular bone connectivity density | "increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: ApcMin/Apc+,Dcctm1Wbg/Dcc+
Genetic Background: involves: C57BL/6J
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