ENSMUSG00000002279


Mus musculus

Features
Gene ID: ENSMUSG00000002279
  
Biological name :Lmf1
  
Synonyms : Lipase maturation factor 1 / Lmf1 / Q3U3R4
  
Possible biological names infered from orthology : Q96S06
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 25579174
Gene end: 25662826
  
Corresponding Affymetrix probe sets: 10442816 (MoGene1.0st)   1424259_at (Mouse Genome 430 2.0 Array)   1445833_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114651
Ensembl peptide - ENSMUSP00000112340
Ensembl peptide - ENSMUSP00000119563
Ensembl peptide - ENSMUSP00000129263
Ensembl peptide - ENSMUSP00000066682
NCBI entrez gene - 76483     See in Manteia.
MGI - MGI:1923733
RefSeq - NM_029624
RefSeq - XM_006525095
RefSeq - XM_006525096
RefSeq Peptide - NP_083900
swissprot - Z4YJR1
swissprot - D6RDS1
swissprot - F6RND1
swissprot - F6YC79
swissprot - Q3U3R4
Ensembl - ENSMUSG00000002279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01073168.1ENSDARG00000102861Danio rerio
 LMF1ENSGALG00000044187Gallus gallus
 LMF1ENSG00000103227Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmf2 / Q8C3X8 / Lipase maturation factor 2 / Q9BU23*ENSMUSG0000002261429


Protein motifs (from Interpro)
Interpro ID Name
 IPR009613  Lipase maturation factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0009306 protein secretion IMP
 biological_processGO:0033578 protein glycosylation in Golgi IMP
 biological_processGO:0034382 chylomicron remnant clearance IMP
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IMP
 biological_processGO:0051604 protein maturation IDA
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 biological_processGO:0090207 regulation of triglyceride metabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009699 hyperchylomicronemia "increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011579 decreased lipoprotein lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmf1cld/Lmf1cld
Genetic Background: Not Specified

Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011582 decreased triglyceride lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032207 Lipc / P27656 / Hepatic triacylglycerol lipase / P11150* / lipase C, hepatic type*  / complex / reaction






 

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