ENSMUSG00000002308


Mus musculus

Features
Gene ID: ENSMUSG00000002308
  
Biological name :Cd320
  
Synonyms : Cd320 / CD320 antigen / Q9Z1P5
  
Possible biological names infered from orthology : CD320 molecule / Q9NPF0
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 33843091
Gene end: 33849774
  
Corresponding Affymetrix probe sets: 10444046 (MoGene1.0st)   1417100_at (Mouse Genome 430 2.0 Array)   1448588_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002379
Ensembl peptide - ENSMUSP00000084839
NCBI entrez gene - 54219     See in Manteia.
MGI - MGI:1860083
RefSeq - NM_001305169
RefSeq - NM_019421
RefSeq Peptide - NP_001292098
RefSeq Peptide - NP_062294
swissprot - Q9Z1P5
Ensembl - ENSMUSG00000002308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD320ENSG00000167775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0015889 cobalamin transport ISO
 biological_processGO:0030656 regulation of vitamin metabolic process IMP
 biological_processGO:0030890 positive regulation of B cell proliferation ISS
 biological_processGO:0031296 B cell costimulation ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0031419 cobalamin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-88H/Oca2p
Genetic Background: involves: 101/H

 MP:0004019 abnormal vitamin homeostasis "anomaly in the state of equilibrium in the body of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0011227 abnormal vitamin B12 level "any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom" [GO:0009236]
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Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020432 Tcn2 / O88968 / Transcobalamin-2 / P20062*  / reaction / complex






 

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