ENSMUSG00000002968


Mus musculus

Features
Gene ID: ENSMUSG00000002968
  
Biological name :Med25
  
Synonyms : Med25 / Mus musculus mediator complex subunit 25 (Med25), transcript variant 3, mRNA. / Q8VCB2
  
Possible biological names infered from orthology : mediator complex subunit 25 / Q71SY5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44876765
Gene end: 44892712
  
Corresponding Affymetrix probe sets: 10562942 (MoGene1.0st)   1448637_at (Mouse Genome 430 2.0 Array)   1453197_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146405
Ensembl peptide - ENSMUSP00000147117
Ensembl peptide - ENSMUSP00000146864
Ensembl peptide - ENSMUSP00000146817
Ensembl peptide - ENSMUSP00000146676
Ensembl peptide - ENSMUSP00000146595
Ensembl peptide - ENSMUSP00000146498
Ensembl peptide - ENSMUSP00000146475
Ensembl peptide - ENSMUSP00000146422
Ensembl peptide - ENSMUSP00000003049
NCBI entrez gene - 75613     See in Manteia.
MGI - MGI:1922863
RefSeq - XM_017312367
RefSeq - XM_006541261
RefSeq - XM_017312366
RefSeq - XM_006541266
RefSeq - XM_006541265
RefSeq - XM_006541264
RefSeq - XM_006541263
RefSeq - NM_001331207
RefSeq - NM_001331208
RefSeq - NM_029365
RefSeq - XM_017312368
RefSeq - XM_006541262
RefSeq Peptide - NP_001318136
RefSeq Peptide - NP_001318137
RefSeq Peptide - NP_083641
swissprot - Q8VCB2
swissprot - A0A140LJ84
swissprot - A0A140LHG7
swissprot - A0A140LHI1
swissprot - A0A140LHM8
swissprot - A0A140LHQ0
swissprot - A0A140LI51
swissprot - A0A140LIH0
swissprot - A0A140LIL1
Ensembl - ENSMUSG00000002968
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MED25ENSG00000104973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptov1 / Q91VU8 / Prostate tumor-overexpressed 1 protein homolog / Q86YD1* / prostate tumor overexpressed 1*ENSMUSG0000003850222


Protein motifs (from Interpro)
Interpro ID Name
 IPR021394  Mediator complex, subunit Med25, PTOV domain
 IPR021397  Mediator complex, subunit Med25, synapsin 1
 IPR021406  Mediator complex, subunit Med25, NR box
 IPR021419  Mediator complex, subunit Med25, von Willebrand factor type A
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0035563 positive regulation of chromatin binding ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISO
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:2001178 positive regulation of mediator complex assembly ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0044798 nuclear transcription factor complex IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0042974 retinoic acid receptor binding IPI
 molecular_functionGO:0046965 retinoid X receptor binding IPI


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr