ENSMUSG00000002992


Mus musculus

Features
Gene ID: ENSMUSG00000002992
  
Biological name :Apoc2
  
Synonyms : Apoc2 / Apolipoprotein C-II / Q05020
  
Possible biological names infered from orthology : apolipoprotein C2 / P02655
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19671579
Gene end: 19677941
  
Corresponding Affymetrix probe sets: 10560608 (MoGene1.0st)   1418069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003074
Ensembl peptide - ENSMUSP00000115173
Ensembl peptide - ENSMUSP00000118291
NCBI entrez gene - 11813     See in Manteia.
MGI - MGI:88054
RefSeq - NM_001277944
RefSeq - NM_001309795
RefSeq Peptide - NP_001264873
RefSeq Peptide - NP_001296724
swissprot - Q05020
swissprot - Q3UJG0
Ensembl - ENSMUSG00000002992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOC2ENSG00000234906Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q05020 / Gm44805 / predicted gene 44805 / APOC2* / P02655* / apolipoprotein C2*ENSMUSG00000109350100


Protein motifs (from Interpro)
Interpro ID Name
 IPR008019  Apolipoprotein C-II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0010518 positive regulation of phospholipase activity ISO
 biological_processGO:0010898 positive regulation of triglyceride catabolic process ISO
 biological_processGO:0010916 negative regulation of very-low-density lipoprotein particle clearance ISO
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032375 negative regulation of cholesterol transport ISO
 biological_processGO:0033344 cholesterol efflux ISO
 biological_processGO:0033700 phospholipid efflux ISO
 biological_processGO:0034382 chylomicron remnant clearance ISO
 biological_processGO:0034384 high-density lipoprotein particle clearance ISO
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process ISO
 biological_processGO:0045833 negative regulation of lipid metabolic process ISO
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis ISO
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity ISO
 biological_processGO:0060697 positive regulation of phospholipid catabolic process ISO
 biological_processGO:0070328 triglyceride homeostasis ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034361 very-low-density lipoprotein particle ISO
 cellular_componentGO:0034362 low-density lipoprotein particle ISO
 cellular_componentGO:0034363 intermediate-density lipoprotein particle ISO
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle ISO
 cellular_componentGO:0042627 chylomicron ISO
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0016004 phospholipase activator activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043274 phospholipase binding ISO
 molecular_functionGO:0055102 lipase inhibitor activity ISO
 molecular_functionGO:0060230 lipoprotein lipase activator activity ISO


Pathways (from Reactome)
Pathway description
Chylomicron assembly
Chylomicron remodeling
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em1Arem/Apoc2+
Genetic Background: involves: C57BL/6 * FVB/NJ

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Apoc2em2Arem/Apoc2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em2Arem/Apoc2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em1Arem/Apoc2+
Genetic Background: involves: C57BL/6 * FVB/NJ

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Apoc2em2Arem/Apoc2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

 MP:0010329 abnormal lipoprotein level "any anomaly in the concentrations of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

Allelic Composition: Apoc2em2Arem/Apoc2em2Arem
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr