ENSMUSG00000003131


Mus musculus

Features
Gene ID: ENSMUSG00000003131
  
Biological name :Pafah1b2
  
Synonyms : Pafah1b2 / Platelet-activating factor acetylhydrolase IB subunit beta / Q61206
  
Possible biological names infered from orthology : P68402 / platelet activating factor acetylhydrolase 1b catalytic subunit 2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 45962859
Gene end: 46012690
  
Corresponding Affymetrix probe sets: 10593159 (MoGene1.0st)   1422791_at (Mouse Genome 430 2.0 Array)   1422792_at (Mouse Genome 430 2.0 Array)   1422793_at (Mouse Genome 430 2.0 Array)   1430361_at (Mouse Genome 430 2.0 Array)   1439868_at (Mouse Genome 430 2.0 Array)   1450755_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148931
Ensembl peptide - ENSMUSP00000151196
Ensembl peptide - ENSMUSP00000150013
Ensembl peptide - ENSMUSP00000149998
Ensembl peptide - ENSMUSP00000149819
Ensembl peptide - ENSMUSP00000149409
Ensembl peptide - ENSMUSP00000149204
Ensembl peptide - ENSMUSP00000127851
NCBI entrez gene - 18475     See in Manteia.
MGI - MGI:108415
RefSeq - XM_017313208
RefSeq - XM_006510081
RefSeq - XM_017313207
RefSeq - XM_006510085
RefSeq - XM_006510084
RefSeq - XM_017313209
RefSeq - NM_008775
RefSeq Peptide - NP_001344173
RefSeq Peptide - NP_001344170
RefSeq Peptide - NP_001344172
RefSeq Peptide - NP_001344174
RefSeq Peptide - NP_032801
swissprot - Q61206
swissprot - A0A1L1SVK0
swissprot - A0A1L1SQ76
swissprot - A0A1L1SQV7
swissprot - A0A1L1SRD0
swissprot - A0A1L1SSP3
swissprot - A0A1L1SSQ5
Ensembl - ENSMUSG00000003131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pafah1b2ENSDARG00000035352Danio rerio
 PAFAH1B2ENSGALG00000027918Gallus gallus
 P68402ENSG00000168092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61205 / Pafah1b3 / Platelet-activating factor acetylhydrolase IB subunit gamma / Q15102* / platelet activating factor acetylhydrolase 1b catalytic subunit 3*ENSMUSG0000000544758


Protein motifs (from Interpro)
Interpro ID Name
 IPR013830  SGNH hydrolase-type esterase domain
 IPR036514  SGNH hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007420 brain development IBA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0016239 positive regulation of macroautophagy ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047179 platelet-activating factor acetyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla,Pafah1b3tm1Cla/Pafah1b3tm1Cla
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005447 Q61205 / Pafah1b3 / Platelet-activating factor acetylhydrolase IB subunit gamma / Q15102* / platelet activating factor acetylhydrolase 1b catalytic subunit 3*  / complex
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex






 

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