ENSG00000168092


Homo sapiens

Features
Gene ID: ENSG00000168092
  
Biological name :PAFAH1B2
  
Synonyms : P68402 / PAFAH1B2 / platelet activating factor acetylhydrolase 1b catalytic subunit 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 117144267
Gene end: 117176894
  
Corresponding Affymetrix probe sets: 1569431_at (Human Genome U133 Plus 2.0 Array)   210160_at (Human Genome U133 Plus 2.0 Array)   224777_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388742
Ensembl peptide - ENSP00000434951
Ensembl peptide - ENSP00000435289
Ensembl peptide - ENSP00000304006
Ensembl peptide - ENSP00000431365
NCBI entrez gene - 5049     See in Manteia.
OMIM - 602508
RefSeq - XM_017017840
RefSeq - NM_001184746
RefSeq - NM_001184747
RefSeq - NM_001184748
RefSeq - NM_001309431
RefSeq - NM_002572
RefSeq Peptide - NP_001171675
RefSeq Peptide - NP_001171676
RefSeq Peptide - NP_001171677
RefSeq Peptide - NP_001296360
RefSeq Peptide - NP_002563
swissprot - P68402
swissprot - V9HW44
swissprot - J3KNE3
Ensembl - ENSG00000168092
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pafah1b2ENSDARG00000035352Danio rerio
 PAFAH1B2ENSGALG00000027918Gallus gallus
 Q61206ENSMUSG00000003131Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15102 / PAFAH1B3 / platelet activating factor acetylhydrolase 1b catalytic subunit 3ENSG0000007946258


Protein motifs (from Interpro)
Interpro ID Name
 IPR013830  SGNH hydrolase-type esterase domain
 IPR036514  SGNH hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007420 brain development IBA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047179 platelet-activating factor acetyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000079462 Q15102 / PAFAH1B3 / platelet activating factor acetylhydrolase 1b catalytic subunit 3  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex






 

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