ENSMUSG00000004069


Mus musculus

Features
Gene ID: ENSMUSG00000004069
  
Biological name :Dnaja3
  
Synonyms : Dnaja3 / DnaJ homolog subfamily A member 3, mitochondrial / Q99M87
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member A3 / Q96EY1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4639989
Gene end: 4707695
  
Corresponding Affymetrix probe sets: 10433278 (MoGene1.0st)   1420629_a_at (Mouse Genome 430 2.0 Array)   1432066_at (Mouse Genome 430 2.0 Array)   1449935_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053842
Ensembl peptide - ENSMUSP00000111520
Ensembl peptide - ENSMUSP00000155588
NCBI entrez gene - 83945     See in Manteia.
MGI - MGI:1933786
RefSeq - NM_001135112
RefSeq - NM_023646
RefSeq Peptide - NP_001128584
RefSeq Peptide - NP_076135
swissprot - Q3TJA9
swissprot - Q99M87
Ensembl - ENSMUSG00000004069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaja3aENSDARG00000058494Danio rerio
 dnaja3bENSDARG00000102295Danio rerio
 DNAJA3ENSGALG00000007821Gallus gallus
 DNAJA3ENSG00000103423Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80TN4 / Dnajc16 / DnaJ homolog subfamily C member 16 / Q9Y2G8* / DnaJ heat shock protein family (Hsp40) member C16*ENSMUSG0000004069720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001305  Heat shock protein DnaJ, cysteine-rich domain
 IPR001623  DnaJ domain
 IPR002939  Chaperone DnaJ, C-terminal
 IPR008971  HSP40/DnaJ peptide-binding
 IPR012724  Chaperone DnaJ
 IPR018253  DnaJ domain, conserved site
 IPR036410  Heat shock protein DnaJ, cysteine-rich domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006264 mitochondrial DNA replication IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0006924 activation-induced cell death of T cells IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IDA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0034341 response to interferon-gamma ISO
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043069 negative regulation of programmed cell death IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008385 IkappaB kinase complex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex ISO
 cellular_componentGO:0042645 mitochondrial nucleoid ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005133 interferon-gamma receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0030695 GTPase regulator activity IDA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051059 NF-kappaB binding ISO
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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