Manteia

ENSMUSG00000005043

Mus musculus

Features

Gene ID:	ENSMUSG00000005043

Biological name :	Sgsh

Synonyms :	N-sulfoglucosamine sulfohydrolase (sulfamidase) / Sgsh

Possible biological names infered from orthology :	N-sulfoglucosamine sulfohydrolase / P51688

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	E2
Gene start:	119343425
Gene end:	119355536

Corresponding Affymetrix probe sets:	10393648 (MoGene1.0st) 1422988_at (Mouse Genome 430 2.0 Array) 1438731_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000097748 Ensembl peptide - ENSMUSP00000115587 Ensembl peptide - ENSMUSP00000005173 NCBI entrez gene - 27029 See in Manteia. MGI - MGI:1350341 RefSeq - NM_018822 RefSeq Peptide - NP_061292 swissprot - Q9EQ08 swissprot - B1ATE0 swissprot - G3XA02 Ensembl - ENSMUSG00000005043

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sgsh	ENSDARG00000032087	Danio rerio
SGSH	ENSGALG00000007027	Gallus gallus
SGSH	ENSG00000181523	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000917	Sulfatase, N-terminal
IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
IPR017850	Alkaline-phosphatase-like, core domain superfamily
IPR024607	Sulfatase, conserved site
IPR032506	Domain of unknown function DUF4976

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006027	glycosaminoglycan catabolic process	ISO
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0030200	heparan sulfate proteoglycan catabolic process	ISO
biological_process	GO:0030201	heparan sulfate proteoglycan metabolic process	TAS
cellular_component	GO:0005764	lysosome	TAS
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008484	sulfuric ester hydrolase activity	ISS
molecular_function	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	ISO
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

HS-GAG degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000285	abnormal cardiac valve morphology	"malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000539	distended urinary bladder	"stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001511	disheveled coat	"coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0002074	abnormal hair texture	"irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0002703	abnormal renal tubules	"anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0003795	abnormal bone structure		Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005058	abnormal lysosome morphology	"anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0005419	hypoalbuminemia	"blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pip5k1c^{tm1a(KOMP)Wtsi}/Pip5k1c^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Pip5k1c^{tm1a(KOMP)Wtsi}/Wtsi
MP:0030278	thick neurocranium	"increased thickness of the bones of the skull enclosing the brain" [MGI:anna]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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