ENSMUSG00000005103


Mus musculus

Features
Gene ID: ENSMUSG00000005103
  
Biological name :Wdr1
  
Synonyms : O88342 / Wdr1 / WD repeat domain 1
  
Possible biological names infered from orthology : O75083
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 38526813
Gene end: 38563221
  
Corresponding Affymetrix probe sets: 10529689 (MoGene1.0st)   1423054_at (Mouse Genome 430 2.0 Array)   1437591_a_at (Mouse Genome 430 2.0 Array)   1450851_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005234
Ensembl peptide - ENSMUSP00000143937
NCBI entrez gene - 22388     See in Manteia.
MGI - MGI:1337100
RefSeq - XM_006503863
RefSeq - NM_011715
RefSeq Peptide - NP_035845
swissprot - O88342
swissprot - Q3TJY2
swissprot - A0A0J9YU05
Ensembl - ENSMUSG00000005103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WDR1ENSDARG00000114022Danio rerio
 WDR1ENSGALG00000014957Gallus gallus
 WDR1ENSG00000071127Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011045  Nitrous oxide reductase, N-terminal
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002446 neutrophil mediated immunity IMP
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030043 actin filament fragmentation IMP
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0030834 regulation of actin filament depolymerization IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IGI
 biological_processGO:0030865 cortical cytoskeleton organization IMP
 biological_processGO:0042247 establishment of planar polarity of follicular epithelium IMP
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0048713 regulation of oligodendrocyte differentiation ISO
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP
 biological_processGO:1990266 neutrophil migration IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030864 cortical actin cytoskeleton IBA
 cellular_componentGO:0042643 actomyosin, actin portion IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Wdr1rede/Wdr1rede
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Wdr1rede/Wdr1rede
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Wdr1rede/Wdr1rede
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Wdr1rede/Wdr1rede
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003405 abnormal platelet shape 
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0004721 abnormal platelet dense granule morphology "any structural anomaly of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010570 prolonged ST segment "increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,Tg(Myhc-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Wdr1Gt(XN462)Byg/Wdr1rede
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014060 abnormal platelet alpha-granule morphology "any structural anomaly of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
Show

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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