ENSMUSG00000005198


Mus musculus

Features
Gene ID: ENSMUSG00000005198
  
Biological name :Polr2a
  
Synonyms : DNA-directed RNA polymerase II subunit RPB1 / P08775 / Polr2a
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69733997
Gene end: 69758637
  
Corresponding Affymetrix probe sets: 10387588 (MoGene1.0st)   1422311_a_at (Mouse Genome 430 2.0 Array)   1426242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071200
Ensembl peptide - ENSMUSP00000050771
NCBI entrez gene - 20020     See in Manteia.
MGI - MGI:98086
RefSeq - NM_001291068
RefSeq Peptide - NP_001277997
swissprot - A0A0R4J0V5
swissprot - P08775
Ensembl - ENSMUSG00000005198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr2aENSDARG00000099966Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polr3a / polymerase (RNA) III (DNA directed) polypeptide A / O14802* / RNA polymerase III subunit A*ENSMUSG0000002528025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000684  RNA polymerase II, heptapeptide repeat, eukaryotic
 IPR000722  RNA polymerase, alpha subunit
 IPR006592  RNA polymerase, N-terminal
 IPR007066  RNA polymerase Rpb1, domain 3
 IPR007073  RNA polymerase Rpb1, domain 7
 IPR007075  RNA polymerase Rpb1, domain 6
 IPR007080  RNA polymerase Rpb1, domain 1
 IPR007081  RNA polymerase Rpb1, domain 5
 IPR007083  RNA polymerase Rpb1, domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006353 DNA-templated transcription, termination ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0033120 positive regulation of RNA splicing ISO
 biological_processGO:0071453 cellular response to oxygen levels IEA
 cellular_componentGO:0000974 Prp19 complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005665 DNA-directed RNA polymerase II, core complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001055 RNA polymerase II activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0001234 absent suprabasal layer "missing suprobasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Fntbtm1Bbd/Fntbtm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Braftm1Mmcm/Braf+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atoh1tm1(cre)Gan/Atoh1tm1(cre)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv

Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Sva/Braftm1Sva,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g)Tvrd/Polr2aTn(pb-CAG-GCaMP5g)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: Not Specified

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Polr2atm2Cdn/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: Not Specified

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2a+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm1Nbr/Mapk14tm2Nbr,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+,Tg(BCL2)#Wehi/0
Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+,Tg(BCL2)#Wehi/0
Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: C57BL/6 * SJL

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009560 absent epidermis stratum granulosum "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk14tm2Nbr/Mapk14+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc20tm1.1Mama/Cdc20tm1.2Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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