ENSMUSG00000005371


Mus musculus

Features
Gene ID: ENSMUSG00000005371
  
Biological name :Fbxo11
  
Synonyms : Fbxo11 / Mus musculus F-box protein 11 (Fbxo11), transcript variant 2, mRNA. / Q7TPD1
  
Possible biological names infered from orthology : F-box protein 11 / Q86XK2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 87990859
Gene end: 88065291
  
Corresponding Affymetrix probe sets: 10453461 (MoGene1.0st)   1434108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005504
Ensembl peptide - ENSMUSP00000121206
Ensembl peptide - ENSMUSP00000138653
NCBI entrez gene - 225055     See in Manteia.
MGI - MGI:2147134
RefSeq - XM_006524204
RefSeq - NM_001081034
RefSeq - NM_001348248
RefSeq - XM_006524203
RefSeq Peptide - NP_001335177
RefSeq Peptide - NP_001074503
swissprot - Q7TPD1
swissprot - S4R2I0
swissprot - F6T356
Ensembl - ENSMUSG00000005371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo11aENSDARG00000061631Danio rerio
 FBXO11ENSGALG00000008944Gallus gallus
 FBXO11ENSG00000138081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxo10 / Q7TQF2 / F-box only protein 10 / Q9UK96* / F-box protein 10*ENSMUSG0000004823220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR003126  Zinc finger, UBR-type
 IPR006626  Parallel beta-helix repeat
 IPR006633  Carbohydrate-binding/sugar hydrolysis domain
 IPR007742  Periplasmic copper-binding protein NosD, beta helix domain
 IPR011050  Pectin lyase fold/virulence factor
 IPR012334  Pectin lyase fold
 IPR022441  Parallel beta-helix repeat-2
 IPR029799  F-box only protein 11
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Allelic Composition: Fbxo11Mutt/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Allelic Composition: Fbxo11Mutt/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: involves: BALB/c

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003330 abnormal auditory tube "anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Mutt/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0009603 absent keratohyalin granules "absence of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fbxo11Mutt/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
Show

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Allelic Composition: Fbxo11Mutt/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0030154 abnormal tympanic cavity morphology "any structural anomaly of the small, air-filled, mucosa-lined cavity that is located in the petrous portion of the temporal bone and houses the auditory ossicles and intratympanic muscles (tensor tympani and stapedius) as well as the chorda tympani and the tympanic plexus of nerves; it is split into two parts: the tympanic cavity proper (the space directly internal to the tympanic membrane) and the epitympanic recess or attic (the space superior to the tympanic membrane)" []
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0030226 middle ear polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the middle ear" [MGI:anna]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl

 MP:0030410 middle ear effusion "fluid accumulation in the middle ear cavity due to dysfunction of the Eustachian tube" [https://www.medscape.org/viewarticle/730698, PMID:1267372]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Fbxo11Jf/Fbxo11+
Genetic Background: involves: BALB/cAnNCrl

 MP:0030413 tympanic membrane retraction "a condition in which a segment of the tympanic membrane (eardrum) collapses inwards towards the middle ear space and lies more medially (deeper) than its normal position; the retracted segment is often known as a retraction pocket" [http://allearseducation.org/resources/Tutorial-10-Retractions.pdf, https://en.wikipedia.org/wiki/Tympanic_membrane_retraction]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0030419 excessive cerumen "excess buildup of cerumen, a yellowish waxy substance (earwax), in the external auditory canal" [HP:0030789]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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