ENSMUSG00000005413


Mus musculus

Features
Gene ID: ENSMUSG00000005413
  
Biological name :Hmox1
  
Synonyms : Heme oxygenase 1 / Hmox1 / P14901
  
Possible biological names infered from orthology : P09601
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C1
Gene start: 75093621
Gene end: 75100589
  
Corresponding Affymetrix probe sets: 10572897 (MoGene1.0st)   1448239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005548
NCBI entrez gene - 15368     See in Manteia.
MGI - MGI:96163
RefSeq - NM_010442
RefSeq Peptide - NP_034572
swissprot - P14901
swissprot - Q3U5U6
Ensembl - ENSMUSG00000005413
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmox1aENSDARG00000027529Danio rerio
 HMOX1ENSGALG00000012550Gallus gallus
 HMOX1ENSG00000100292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmox2 / O70252 / Mus musculus heme oxygenase 2 (Hmox2), transcript variant 3, mRNA. / P30519* / heme oxygenase 2*ENSMUSG0000000407046


Protein motifs (from Interpro)
Interpro ID Name
 IPR002051  Haem oxygenase
 IPR016053  Haem oxygenase-like
 IPR016084  Haem oxygenase-like, multi-helical
 IPR018207  Haem oxygenase conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002246 wound healing involved in inflammatory response IEA
 biological_processGO:0006788 heme oxidation ISO
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0016242 negative regulation of macroautophagy IMP
 biological_processGO:0031670 cellular response to nutrient IEA
 biological_processGO:0032764 negative regulation of mast cell cytokine production IEA
 biological_processGO:0034101 erythrocyte homeostasis IEA
 biological_processGO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron IDA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042167 heme catabolic process IEA
 biological_processGO:0042168 heme metabolic process IDA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043305 negative regulation of mast cell degranulation IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071243 cellular response to arsenic-containing substance IDA
 biological_processGO:0071276 cellular response to cadmium ion IDA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072719 cellular response to cisplatin IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:1904036 negative regulation of epithelial cell apoptotic process IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004392 heme oxygenase (decyclizing) activity ISO
 molecular_functionGO:0004630 phospholipase D activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Heme degradation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf4atm2Mwei/Hnf4atm2Mwei
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hnf4atm2Mwei/Hnf4atm2Mwei
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011854 cerebral edema "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Hmox1tm1Poss/Hmox1tm1Poss
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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